E45 treatment for dry skin conditions?. skin care you can trust. An effective moisturiser that?s pleasant to use, E45 Cream has been clinically proven to treat and soothe dry, itching, flaking, chapped, rough and calloused skin, sunburn and detergent hands. It can also be helpful in soothing eczema. E45?s non-greasy emollient formulation is quickly absorbed by your skin, leaving it soft, comfortable and relieved. This skin care product is perfume free, dermatologically tested and clinically proven.