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Flurizin 10 mgFlurizin 10 mg is indicated for Prophylaxis of classic (with aura) or common (without aura) migraine Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system). Peripheral Vascular Disease (PVD) Motion sickness Refractory epilepsy resistant to conventional antiepileptic therapy. Theropeutic ClassMiscellaneous prophylactic migraine preparationsPharmacologyFlurizin 10 mg is the difluorinated derivative of cinnarizine. It is a selective calcium channel antagonist. By reducing excessive transmembrane influx of calcium Flurizin 10 mg prevents cellular calcium overload. It does not interfere with normal cellular calcium homeostasis. Flurizin 10 mg also has some antihistaminic and sedative properties. It binds at an affinity of 99% to plasma protein.Dosage & Administration of Flurizin 10 mgMigraine Prophylaxis: Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. If, during this treatment depressive, extrapyramidal or other unacceptable symptoms occur, administration should be discontinued. If, after 2 months of this initial treatment, no significant improvement is observed, the patient should be considered a non-responder and administration should be discontinued. Maintenance Treatment: If a patient is responding satisfactorily and if a maintenance treatment is needed, the dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week. Even if the prophylactic maintenance treatment is successful and well tolerated, it should be interrupted after 6 months and it should be re-initiated only if the patient relapses. Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required.Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg).Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapyDosage of Flurizin 10 mgMigraine Prophylaxis: Starting Dose: 10 mg at night in patients less than 65 years of age and 5 mg daily in patients older than 65 years. If, during this treatment depressive, extrapyramidal or other unacceptable symptoms occur, administration should be discontinued. If, after 2 months of this initial treatment, no significant improvement is observed, the patient should be considered a non-responder and administration should be discontinued. Maintenance Treatment: If a patient is responding satisfactorily and if a maintenance treatment is needed, the dose should be decreased to 5 days treatment at the same daily dose with two successive medicine free days every week. Even if the prophylactic maintenance treatment is successful and well tolerated, it should be interrupted after 6 months and it should be re-initiated only if the patient relapses. Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required.Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg).Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapyInteraction of Flurizin 10 mgGalactorrhoea has been reported in few women on oral contraceptives within the first two months of Flurizin 10 mg treatment. Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Flurizin 10 mg by increasing its metabolism. So an increase in dosage of Flurizin 10 mg may be required.ContraindicationsHypersensitivity to Flurizin 10 mg. Flurizin 10 mg is contra-indicated in patients with a history of depressive illness, or with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders.Side Effects of Flurizin 10 mgDrowsiness and/or fatigue, as well as weight gain and/or increased appetite may occur. The following adverse experiences have been reported during chronic treatment with Flurizin 10 mg: depression, of which female patients with a history of depressive illness may be particularly at risk; extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor), of which elderly patients seem particularly at risk. Infrequently reported adverse reaction are: heartburn; nausea; gastralgia; insomnia; anxiety; galactorrhoea; dry mouth; muscle ache; skin rash.Pregnancy & LactationSafety in pregnancy and lactation has not been established.Precautions & WarningsFlurizin 10 mg may lead to drowsiness which is aggravated by the simultaneous intake of alcohol or other central nervous system depressants. Patients should be cautioned against driving motor vehicles or performing other potentially hazardous tasks where a loss of mental alertness may lead to accidents. Flurizin 10 mg is not suited for aborting a migraine attack. The possible occurrence of an attack is therefore no reason to increase the dose of Flurizin 10 mg. This treatment may give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism, especially in predisposed patients such as the elderly. Flurizin 10 mg should therefore be used with caution in such patients.Storage ConditionsKeep below 30?C temperature, away from light & moisture. Keep out of the reach of children.Drug ClassesMiscellaneous prophylactic migraine preparationsMode Of ActionFlurizin 10 mg is the difluorinated derivative of cinnarizine. It is a selective calcium channel antagonist. By reducing excessive transmembrane influx of calcium Flurizin 10 mg prevents cellular calcium overload. It does not interfere with normal cellular calcium homeostasis. Flurizin 10 mg also has some antihistaminic and sedative properties. It binds at an affinity of 99% to plasma protein.PregnancySafety in pregnancy and lactation has not been established.