HEALGRAFT 500 Tablet 10?s Allschoolabs -

Specification

INTRODUCTION
HEALGRAFT 500 TABLET contains Mycophenolate mofetil which belongs to the group of medicines called Immunosuppressants. It is used to prevent your body rejecting a transplanted organ (such as kidney, heart, and liver). It is also given with other medications such as corticosteroids and ciclosporin.
Your doctor will perform some regular blood tests to monitor any changes in your body. HEALGRAFT 500 TABLET may increases the risk of skin cancer. Limit your exposure to sunlight and ultraviolet light by covering the exposed areas of skin as much as possible and by applying sunscreen with a high protective factor.
HEALGRAFT 500 TABLET can cause birth defects and miscarriage, hence it is strictly not recommended for use in pregnant women and breastfeeding women.
HEALGRAFT 500 TABLET is not recommended for use in children under 2 years of age. Contact your doctor before taking.
HEALGRAFT 500 TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking HEALGRAFT 500 TABLET.
The most common side effects of taking HEALGRAFT 500 TABLET are nausea, vomiting, diarrhea, stomach pain, headache, high blood pressure, and low number of white blood cells. Contact your doctor if the above side effects worsen.
USES OF HEALGRAFT 500 TABLET

Used to prevent your body rejecting a transplanted organ (such as kidney, heart, and liver)

HOW HEALGRAFT 500 TABLET WORKS
HEALGRAFT 500 TABLET belongs to immunosuppressants which reduces the action of the body?s own defense system (the immune system) and prevents rejection of the transplanted organ.
DIRECTIONS FOR USE
Take HEALGRAFT 500 TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your dosage will vary depending on the type of transplant you received. Do not stop the medicine suddenly without the concern of your doctor.
SIDE EFFECTS OF HEALGRAFT 500 TABLET

COMMON

Decreased white blood cells

Decrease in calcium levels of blood

Abnormal potassium levels in the blood (high or low)

Raised uric acid levels in the blood

High or low blood pressure

Anxiety

Diarrhoea

Joint or muscle pain

Tiredness, shortness of breath and pale skin (decrease in red blood cells)

Unexpected bleeding and bruising (decrease in blood platelets)

Hypomagnesemia (decrease in magnesium levels of blood)

Dizziness

Headache

Cough

Shortness of breath

Stomach pain, inflammation of the lining of the stomach, abdominal bloating, constipation, indigestion, flatulence, loose stools, nausea, vomiting

Tiredness

Fever

Change in liver and kidney function test results

Respiratory infection

Acne

Weakness

Swelling of hands, ankles, or feet

Itching

UNCOMMON

Fast heartbeat or irregular heartbeat

Fluid in the lungs ?

Presence of cyst in lymph ?

Trembling, difficulty in sleeping

Conjunctivitis, blurry vision

Bad breath, gas formation, intestinal blockage, ulcers on lips, heartburn, discoloration of tongue, dry mouth, inflammation of the gums

Loss of appetite

Wheezing

Blockage of salivary glands

Elevated lipid levels

Increase in blood glucose levels or blood cholesterol levels

Strange dreams, delusions

Pain, rigors

Inability to keep an erection

Cough, difficulty breathing, painful breathing

Fever, chills, nausea, vomiting, low body temperature, fast heartbeat

RARE
Stop taking HEALGRAFT 500 TABLET and contact your doctor immediately if you experience any of the following side effects:
Yellowish discoloration of skin and whites of eyes, nausea, loss of appetite and dark urine

Persistent cough or become breathlessness

Signs of infection such as fever, chills, sore throat, sweating, feeling tired, drowsy, or lack of energy

Blood vomit blood or blood in stools due stomach, or intestinal ulcer

Swelling of glands, development of a new skin growth or enlargement of an existing skin growth, or changes in an existing mole. may lead to development of cancer of the skin or lymph nodes

Rashes, swelling of face, lips, tongue or throat causing difficulty breathing

HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink plenty of water and fruit juice to keep yourself hydrated. Contact your doctor if the diarrhea did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the headache did not improve.
Nausea and Vomiting:
Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if nausea and vomiting did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not drink alcohol, as it can aggravate your dizziness. Contact your doctor if the dizziness did not improve.
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain did not improve.
WARNING & PRECAUTIONS

PREGNANCY
HEALGRAFT 500 TABLET is not recommended for use in pregnant women. Inform your doctor if you are planning to have a child before taking this medicine. Contact your doctor before taking HEALGRAFT 500 TABLET.
BREASTFEEDING
HEALGRAFT 500 TABLET is generally not recommended for use in breastfeeding women, hence small amounts of the medicine can pass into the mother?s milk. Contact your doctor before taking HEALGRAFT 500 TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel drowsiness, somnolence, dizziness, tremor, low blood pressure, numb or confusion after taking HEALGRAFT 500 TABLET.
KIDNEY
HEALGRAFT 500 TABLET should be used with caution in patients with kidney diseases. Contact your doctor before taking HEALGRAFT 500 TABLET.
LIVER
HEALGRAFT 500 TABLET should be used with caution in patients with liver diseases. Contact your doctor before taking HEALGRAFT 500 TABLET.
ALLERGY
Do not take HEALGRAFT 500 TABLET if you are allergic (hypersensitive) to Mycophenolate mofetil, or to some sugars such as lactose, galactose, or glucose or to other ingredients of this medicine.
LUNGS
HEALGRAFT 500 TABLET should be used with caution in patients with lung diseases. Contact your doctor before taking HEALGRAFT 500 TABLET.
HEART DISEASE
HEALGRAFT 500 TABLET should be used with caution in patients with heart diseases. Contact your doctor before taking HEALGRAFT 500 TABLET.
OTHERS
HEALGRAFT 500 TABLET is not recommended for use if you:
Have hereditary enzyme deficiency such as Lesch-Nyhan (neurogenetic disorder) and Kelley-Seegmiller syndrome (partial deficiency of the enzyme hypoxanthine guanine phosphoribosyl transferase)
Before taking HEALGRAFT 500 TABLET, inform your doctor if you:
Have any unexpected bruising (skin discoloration from a skin or tissue injury) or bleeding

Have digestive problems (such as a stomach ulcer)

Have a rare problem with your metabolism called phenylketonuria (hereditary condition that results in an accumulation of the phenylalanine)

Are planning to get live vaccinations

Have Hepatitis B or C infections

Have skin cancer or lymphoma
Use in pediatrics:
HEALGRAFT 500 TABLET is not recommended for use in children under the age of 2, because there is limited information on its safety and effectiveness. Contact your doctor before taking HEALGRAFT 500 TABLET.
Use in geriatrics:
HEALGRAFT 500 TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking HEALGRAFT 500 TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking HEALGRAFT 500 TABLET, inform your doctor if you are taking any of the following medicine:
Azathioprine, tacrolimus, belatacept, cyclosporine A (suppress your immune system given after a transplant operation)

Cholestyramine (medicine used to treat high cholesterol)

Rifampicin (medicines used to prevent and treat infections such as TB)

Medicines used to treat ulcer problems (antacids such as aluminium hydroxide, magnesium hydroxide, sodium bicarbonate, calcium carbonate or proton pump inhibitors such as omeprazole, rabeprazole, pantoprazole)

Phosphate binders (used to reduce phosphate absorption into the blood is used by patients with chronic renal failure) such as ferric citrate, calcium acetate, sevelamer

Antibiotics (medicines used to treat bacterial infections) amoxicillin and clavulanic acid, doxycycline, ciprofloxacin, clindamycin, metronidazole, azithromycin, trimethoprim/sulfamethoxazole, amikacin, cefadroxil, norfloxacin

Isavuconazole (medicine used to treat fungal infections)

Telmisartan (medicine used to treat high blood pressure)

Activated charcoal (used to treat digestive problems)

Acyclovir or ganciclovir (medicines used to treat viral infections)

Oral contraceptives such as Ex. ethinylestradiol and levonorgestrel (medicines used to prevent pregnancy)

Probenecid (medicines used to treat gout)

Iron salts such as Ex. ferrous sulphate (medicines used to treat iron deficiency)
Overdosage:
If you or anyone else accidentally takes too much of HEALGRAFT 500 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms include nausea, vomiting, diarrhea, and neutropenia.
SYNOPSIS

Drug :?? Mycophenolate mofetil

Pharmacological Category :?? Immunosuppressants

Therapeutic Indication :?? Prevents your body from rejecting a transplanted organ???????????? ? ? ? ? ??

Dosage Forms :?? Tablet, Capsule, Suspension, Oral suspension

MORE INFORMATION

Keep HEALGRAFT 500 TABLET out of the sight and reach of children

Store HEALGRAFT 500 TABLET below 30?C

FAQs ABOUT HEALGRAFT 500 TABLET
What is HEALGRAFT 500 TABLET used for?
HEALGRAFT 500 TABLET is used to prevent your body from rejecting an organ transplant (such as kidney, heart, and liver). Contact your doctor before taking HEALGRAFT 500 TABLET.
Can I use HEALGRAFT 500 TABLET in pregnancy?
No. HEALGRAFT 500 TABLET is strictly not recommended for use in pregnant women unless considered necessary. Contact your doctor before taking HEALGRAFT 500 TABLET.
Is HEALGRAFT 500 TABLET safe?
Yes, HEALGRAFT 500 TABLET is safe and well tolerated. Contact your doctor before taking.
Can I use HEALGRAFT 500 TABLET in children?
No, HEALGRAFT 500 TABLET is not recommended for use in children under the age of 2, because there is limited information on its safety and effectiveness for them. Contact your doctor before taking.
How HEALGRAFT 500 TABLET work?
HEALGRAFT 500 TABLET belongs to immunosuppressants which reduces the action of the body?s own defense system (the immune system) and prevents rejection of the transplanted organ.
Can I use HEALGRAFT 500 TABLET while breast feeding?
No. HEALGRAFT 500 TABLET is generally not recommended for use in breastfeeding women, small amounts of the medicine can pass into the mother?s milk. Contact your doctor before taking it.
REFERENCES
1. KD Tripathi. Immunosuppressant Drugs. Essentials of Medical Pharmacology. Seventh Edition,2013. Page ? 883.
2. Jeffrey J Swigris, Amy L Olson, Aryeh Fischer, David A Lynch, Gregory P Cosgrove, Stephen K Frankel, Richard T Meehan, Kevin K Brown. Uses of Mycophenolate mofetil. National Institute of Health. NLM. National Centre for Biotechnology Information. Pubmed.gov. 2006. [Accessed on 16th July 2022]?https://pubmed.ncbi.nlm.nih.gov/16840379/
3. Novartis Pharma GmbH. Electronic Medicines Compendium (EMC); [Revised on July 2021] [Accessed 16th July 2022]?https://www.medicines.org.uk/emc/files/pil.5560.pdf
4. Roche Products Limited. Electronic Medicines Compendium (EMC); [Revised on January 2022] [Accessed 16th July 2022]?https://www.medicines.org.uk/emc/files/pil.1102.pdf
5. Novartis Pharma GmbH. Electronic Medicines Compendium (EMC); [Revised on July 2021] [Accessed 16th July 2022]?https://www.medicines.org.uk/emc/files/pil.7793.pdf
6. Accord Healthcare B.V. Electronic Medicines Compendium (EMC); [Revised on Oct 2020] [Accessed 16th July 2022]?https://www.medicines.org.uk/emc/files/pil.5989.pdf
7. Roche Pharma AG. European Medical Agency. [Revised in Jan 2021] [Accessed on 16th July 2022]?https://www.ema.europa.eu/en/documents/product-information/cellcept-epar-product-information_en.pdf
8. Biocon. Mycophenolate mofetil. [Accessed on 16th July 2022]?https://www.biocon.com/docs/prescribing_information/nephrology/renodapts540_pi.pd
9.?Hoffmann-La Roche Limited. Mycophenolate mofetil. [Revised on January 2022] [Accessed 16th July 2022]?https://www.rochecanada.com/PMs/CellCept/CellCept_PM_E.pdf
10. Mycophenolate mofetil. Mims.com. [Accessed on 16th July 2022]?https://www.mims.com/india/drug/info/mycophenolic%20acid?type=full&mtype=generic
USEFUL DIAGNOSTIC TESTS