MECORYL NP Tablet 10?s

INTRODUCTION
MECORYL NP TABLET is a combination of Methylcobalamin, Nortriptyline and Pregabalin which belongs to the group of medicines called Vitamins, Antidepressants and Anticonvulsants respectively. It is used to treat diabetic peripheral neuropathic pain with coexistent vitamin B12 deficiency. ??
Neuropathic pain is a form of pain where there is a damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body. ?
Patients taking MECORYL NP TABLET may have thoughts of harming or killing themselves. If at any time you have these thoughts, immediately consult your physician. Avoid consumption of alcohol during treatment with MECORYL NP TABLET as it may cause dizziness.?
Before taking MECORYL NP TABLET, inform your physician if you have liver or kidney problems, diabetes and angioedema. MECORYL NP TABLET is not recommended for use in pregnant women unless advised by the doctor and not recommended for breast-feeding women.
Elderly patients above 65 years of age always should consult the physician before taking it. The most common side effect of MECORYL NP TABLET are dry mouth, dizziness, sleepiness, blurred vision and weight gain. Consult your doctor if any of the side effects worsen over the time.?????
USES OF MECORYL NP TABLET

Treats diabetic peripheral neuropathic pain with coexistent vitamin B12 deficiency

HOW MECORYL NP TABLET WORKS
MECORYL NP TABLET is a combination of methylcobalamin, nortriptyline and pregabalin, where methylcobalamin is a form of vitamin B that helps in the production of myelin (a substance that protects nerve fibers) and regenerates damaged nerve cells. Nortriptyline is a tricyclic antidepressant that increases the chemical messenger levels (serotonin and noradrenaline) that stops the movement of pain signals in the brain. Pregabalin is an anticonvulsant (alpha 2 delta ligand) that decreases pain by altering the calcium channel activity of the nerve cells. Together, methylcobalamin, nortriptyline and pregabalin helps to relieve neuropathic pain (pain from damaged nerves).
DIRECTIONS FOR USE
Always take MECORYL NP TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of MECORYL NP TABLET for you depending upon your age, body weight and disease condition. Do not stop taking MECORYL NP TABLET without informing your doctor.????
SIDE EFFECTS OF MECORYL NP TABLET

COMMON

Dizziness, sleepiness

Trouble concentrating, blurry vision

Dry mouth

Weight gain

Swelling of your hands or feet

RARE
Stop taking MECORYL NP TABLET and contact your physician immediately if you experience any of the following side effects:
Hypersensitivity or allergic reactions (symptoms include skin redness, blisters, hives, rash, dyspnoea and wheezing)

Have feelings of harming or killing themselves

HOW TO MANAGE SIDE EFFECTS
Dry mouth:
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom does not improve. ?
WARNING & PRECAUTIONS

PREGNANCY
MECORYL NP TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it.
BREASTFEEDING
MECORYL NP TABLET is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your physician before taking it.
DRIVING AND USING MACHINES
Do not drive or operate heavy machines if you experience dizziness while taking MECORYL NP TABLET. Consult with your physician for advice before taking the medicine.
ALCOHOL
Consumption of alcohol is not recommended during treatment with MECORYL NP TABLET as it may cause dizziness.
KIDNEY
MECORYL NP TABLET should be used with caution in patients with kidney problems. Consult with your doctor for advice before taking MECORYL NP TABLET.
LIVER
MECORYL NP TABLET should be used with caution in patients with liver problems. Consult with your doctor for advice before taking MECORYL NP TABLET.
ALLERGY
Do not take MECORYL NP TABLET if you are allergic to Methylcobalamin, Nortriptyline, Pregabalin or any other ingredients of this medicine.
OTHERS
Before taking MECORYL NP TABLET, inform your physician if you have:
Angioedema

Diabetes

Major depressive disorder
Use in geriatrics:
MECORYL NP TABLET should be used with caution in elderly patients above 65 years of age. Consult with your physician for advice before taking MECORYL NP TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking MECORYL NP TABLET inform your physician if you are taking any of the following medicines:
Medicines used as opioid analgesics such as oxycodone, tramadol (used to treat severe pain)

Medicine used to treat depression and anxiety (Ex. lorazepam, diazepam, MAO inhibitors like isocarboxazid)

Medicines used to treat gastroesophageal reflux (Ex. cimetidine, ranitidine)

Oral contraceptives such as desogestrel and ethinyl estradiol (used to prevent pregnancy)

Medicines used for cancer chemotherapy (Ex. arsenic trioxide)

Medicines used to treat bacterial infections (Ex. chloramphenicol, azithromycin, clarithromycin and linezolid)

Reserpine (used to treat high blood pressure)

Anticholinergic drugs such as dicyclomine (used to treat the symptoms of irritable bowel syndrome)

Sympathomimetic drugs such as norepinephrine (used to raise blood pressure in emergency condition)
Overdosage:
If you or anyone else accidentally takes too much of MECORYL NP TABLET, consult your physician immediately or visit the nearby hospital.
SYNOPSIS

Drug :?? Methylcobalamin, Nortriptyline, Pregabalin

Pharmacological Category :?? Vitamin, Tricyclic antidepressant and Anticonvulsant

Therapeutic Indication :?? Neuropathic Pain ? ? ? ? ?

Dosage Forms :?? Tablet, Capsule

MORE INFORMATION

Keep MECORYL NP TABLET out of reach to children

Store at room temperature

FAQs ABOUT MECORYL NP TABLET
Q: When to seek medical emergency while taking MECORYL NP TABLET?
A: Stop taking MECORYL NP TABLET and contact your physician immediately if you experience angioedema (symptoms include swelling of the face, mouth (tongue, lips and gums) and neck (throat and larynx)) and have thoughts of harming or killing themselves.
Q: What to do If I forget to take a dose of MECORYL NP TABLET?
A: You should take MECORYL NP TABLET immediately when you remember. If it is time for the next dose skip the missed dose and follow the regular dose schedule. Do not double the dose to match up the missed dose.
Q: Does MECORYL NP TABLET impair my ability to drive?
A: Yes, MECORYL NP TABLET may cause dizziness, do not drive or operate any machines which require concentration because it can impair your ability to work. Follow appropriate precautions before driving or you may ask someone to drive for you after consulting with your physician. ?
Q: What is the precaution to be followed before taking MECORYL NP TABLET?
A: MECORYL NP TABLET is not recommended to use among women who are breast-feeding and pregnant unless advised by the doctor. Before taking MECORYL NP TABLET, inform your physician if you have liver or kidney problems, diabetes and angioedema. It should be used with caution in elderly patients.
Q: Can MECORYL NP TABLET be used in patients with liver or kidney problems?
A: MECORYL NP TABLET should be used with caution in patients with kidney or liver problems. Your doctor may monitor your liver and kidney function test to prevent the risk of any unusual effects. Consult your doctor before taking it. ?
REFERENCES
1. KD. Tripathi. Drugs affecting blood and blood formation. Skeletal Muscle Relaxants. Drugs Used in Mental Illness: Antidepressant and Antianxiety. Antiepileptic Drugs. Drugs Essentials of medical pharmacology. Seventh edition. 2013. Page ? 608, 457, 421.
2. Ram Prabhoo, Atul Panghate, Raj Pavitra Dewda, Balaji More, Tanay Prabhoo, and Rajiv Rana. Efficacy and Tolerability of a Fixed-Dose Combination of Methylcobalamin and Pregabalin in the Management of Painful Neuropathy. North American Journal of Medical Sciences. NIH. National Library of? Medicine, National center for biotechnology information. Pubmed Central. November 2012. [Accessed on 26th July 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503385/
3. Sheena Derry, Philip J Wiffen, Dominic Aldington, R Andrew Moore. Nortriptyline for neuropathic pain in adults. Cochrane Database of Systematic Reviews. NIH. National Library of Medicine, National center for biotechnology information. Pubmed Central. ?January 2015 [Accessed on 26th July 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485407/
4.?Synokem Pharmaceutical Ltd. Pregaba-MNT (Pregabalin, Methylcobalamin and Nortriptyline). Torrent Pharma. [Revised in May 2022] [Accessed on 26th July 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/3088.pdf
5.?Leeford Health Care. Pregabanyl-NTM. [Accessed on 26th July 2022] https://www.leeford.in/product/782/pregabanyl-ntm
6. Leogenic Healthcare. Pregadew Trio [Accessed on 26th July 2022]?https://www.leogenic.com/pregadew-trio-nortriptyline-methylcobalamin-pregabalin-tablets/
7. Akesiss Ltd. Norblend tablet. [Accessed on 26th July 2022]?https://akesiss.com/divisions/glyvo-life/norblend/
8. Krishlar Pharmaceuticals. Kritpre-NP. [Accessed on 26th July 2022]?https://www.krishlarpharma.com/product/kritpre-np/
Net Qty

1 N

Item Weight

17.5 g

Ingredient

METHYLCOBALAMIN 1500 MCG+NORTRIPTYLINE 10 mg+PREGABALIN 75 mg

Hsn Code

30049099

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