Spusoft300 mg

Spusoft 300 mgSpusoft 300 mg is a mucolytic drug used in the treatment of acute and chronic respiratory diseases. It also improves the symptoms associated with short episodes of chronic bronchitis.Theropeutic ClassCough expectorants & mucolyticsPharmacologySpusoft 300 mg is a prodrug that is metabolised into?N-thiodiglycolyl-homocysteine whereby free thiol groups are formed leading to the opening of the disulphide bonds of the bronchial mucoproteins, thus reducing the viscosity of mucus and purulent sputum. It also antagonises the local formation of free radicals and inhibits elastase enzyme activity and bacterial adhesion to epithelial cells.Dosage & Administration of Spusoft 300 mgThe usual dose of elderly patients and adults above 18 years is 1 capsule twice daily for 10 days. But study shows that in chronic cases Spusoft 300 mg can be given up to 12 months or as directed by the physician. Spusoft 300 mg capsule may be taken with or without food.Dosage of Spusoft 300 mgThe usual dose of elderly patients and adults above 18 years is 1 capsule twice daily for 10 days. But study shows that in chronic cases Spusoft 300 mg can be given up to 12 months or as directed by the physician. Spusoft 300 mg capsule may be taken with or without food.ContraindicationsIt is contraindicated to patients who have hypersensitivity to Spusoft 300 mg. It should not be used in patients with creatinine clearance <25 ml/min, or with severe liver failure.Side Effects of Spusoft 300 mgCommon side effect is epigastric pain. Other side effects include headache, cold, taste alterations, nausea, vomiting, diarrhea, angioedema and other skin allergic reactions.Pregnancy & LactationThe use of Spusoft 300 mg in pregnant or breast-feeding women is not recommended.Precautions & WarningsIt should be used with caution in mild liver failure. In that case, should not exceed a dose of 300 mg per day.Storage ConditionsKeep in a dry place away from light and heat. Keep out of reach of childrenUse In Special PopulationsRenal Impairment: CrCl <25 ml/min: Contraindicated.Hepatic Impairment: Mild to moderate: Max: 300 mg daily. Severe: Contraindicated. Drug ClassesCough expectorants & mucolyticsMode Of ActionSpusoft 300 mg is a prodrug that is metabolised into?N-thiodiglycolyl-homocysteine whereby free thiol groups are formed leading to the opening of the disulphide bonds of the bronchial mucoproteins, thus reducing the viscosity of mucus and purulent sputum. It also antagonises the local formation of free radicals and inhibits elastase enzyme activity and bacterial adhesion to epithelial cells.PregnancyThe use of Spusoft 300 mg in pregnant or breast-feeding women is not recommended.Pediatric UsesRenal Impairment: CrCl <25 ml/min: Contraindicated.Hepatic Impairment: Mild to moderate: Max: 300 mg daily. Severe: Contraindicated.