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Jorvan 500 mgJorvan 500 mg is indicated in Rheumatoid arthritis, Osteoarthritis, Neuralgias, Myalgias, Spondylitis, Backaches, Joint pain, Arthralgia, Joint stiffnessTheropeutic ClassHerbal and NutraceuticalsPharmacologyCommiphora mukul: Guggulu is an exudates obtained in the form of oleogum resin from the stem of Commiphora mukul. It has analgesic & anti-inflammatory properties due to the presence of guggulsterone E & Z. Guggulsterone shows anti-inflammatory effect by inhibiting the activation of nuclear factor-kappa-B (NF-kappa-B).Plumbago zeylanicum: Plumbago zeylanicum possesses flavonoids, which are known to inhibit the prostaglandins synthesis. Flavonoids of Plumbago zeylanicum help to reduce pain perception by suppressing pain substances like prostaglandins & bradykinin.It also controls excessive collagenase production.Study reveals that analgesic effect is comparable to that of Indomethacin.Nigela sativa: Nigella sativa contains thymoquinone,which inhibits the effect of nociceptive system or inflammatory mediators and reduces pain. The anti-nociceptive effect of Nigella sativa is comparable with that of Naproxen.Vanda Roxburghii: Vanda Roxburghii reduces pain & inflammation.Heptacosane & octacosan of Vanda roxburghii shows anti-inflammatory activity.Zingiber officinale: Gingerol from Zingiber officinale possesses anti-inflammmatory and analgesic properties. This formulation inhibits production of prostaglandins & leukotrienes that are responsible for pain & inflammation.The sea salt used in the short term performance of these plants helps.This herb acts as a carriermaterialDosage & Administration of Jorvan 500 mgOne capsule 2-3 times a day after meals or as advised by the physician.Interaction of Jorvan 500 mgLarge amounts of guggulu might theoretically increase the side effects of estrogen; decrease the effectiveness of diltiazem. Taking guggulu along with some medications like atorvastatin, ketoconazole, itraconazole& fexofenadine that are broken down by the liver can decreases the effectiveness of medications. Guggulu might increase thyroid hormone in the body.Taking guggulu along with thyroid hormone pills might increase the effects & side effects of thyroid hormone.ContraindicationsNo severe side effects have been observed with Jogaraj guggulu during the clinical practice for the last twenty-five years; however, systematic Phase 1 study with this drug is carried out and general tolerability of Jogaraj guggulu is found good.Maximum tolerable dose is about 9 gm per day.In rare case very high dose than prescribed may lead to stomach irritation, diarrhea, stomatitis & urticaria.Side Effects of Jorvan 500 mgNo severe side effects have been observed with Jogaraj guggulu during the clinical practice for the last twenty-five years; however, systematic Phase 1 study with this drug is carried out and general tolerability of Jogaraj guggulu is found good.Maximum tolerable dose is about 9 gm per day. In rare case very high dose than prescribed may lead to stomach irritation,diarrhea,stomatitis & urticaria.Pregnancy & LactationJogaraj guggulu should not be used during pregnancy or lactation.Storage ConditionsKeep in a cool,dry place & away from direct sun light.Keep the medicine out of children's reach.