Description

?-Conotoxin GI is a peptide inhibitor of nicotinic acetylcholine receptors (nAChRs) originally found in species of Conus snails. ?-Conotoxin GI binds nAChRs at ?? and ?? interfaces. ?-Conotoxin GI decreases peak amplitude and induces tetanic and train-of-four fades, modulating acetylcholine signaling at the neuromuscular junction.