BMS-777607

in Analytical
Sku: 1762986150-2501
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Product Info Cas No. 1196681-44-3 Purity ?99% Formula C25H19ClF2N4O4 Formula Wt. 512.89 Chemical Name N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide IUPAC Name N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide Synonym BMS777607 Solubility DMSO 47 mg/mL (91.63 mM) Water Insoluble Ethanol Insoluble Appearance White to off white powder
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Description

BMS-777607 is an inhibitor of MET and Ron that exhibits anticancer chemotherapeutic activity. BMS-777607 induces polyploidy in breast cancer cells by disrupting spindle formation and inhibiting equatorial alignment and chromosomal segregation. This compound also displays anti-metastatic benefit, inhibiting the motility and invasion of sarcoma cells in vitro and decreasing the number of lung tumor nodules in vivo.

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