BGB-283

Name: BGB-283
SKU: 1762986265-2532
Availability: InStock

in Analytical

Sku: 1762986265-2532

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Features

Product Info Cas No. 1446090-79-4 Purity ?98% Formula C25H17F3N4O3 Formula Wt. 478.43 IUPAC Name 5-({(1R,1aS,6bR)-1-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one Synonym BGB 283, BGB283, Beigene-283, Lifirafenib

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Description

Description

BGB-283 is a dual RAF/EGFR inhibitor. It inhibits BRAF(V600E)-activated ERK phosphorylation and cell proliferation in vitro. This activity slows cell proliferation and tumor growth in BRAF(V600E) colorectal cancer cell lines, something that BRAF inhibitors vemurafenib and dabrafenib have been unable to achieve.

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