Apremilast

in Analytical
Sku: 1762986998-2687
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Product Info Cas No. 608141-41-9 Purity ?98% Formula C23H25N2O7S Formula Wt. 460.51 IUPAC Name N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide Synonym CC-10004; CC10004 Melting Point 156.1?C Solubility Insoluble in water. Slightly soluble in ethanol. Soluble in acetone (20mg/mL), DMSO (80 mg/mL). Appearance White to off white powder
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Description

Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) that is clinically used to treat psoriasis and psoriatic arthritis. Apremilast exhibits anti-inflammatory and immunomodulatory activities, increasing levels of cAMP and IL-10 and decreasing levels of iNOS, IL-23, and TNF-? in vitro and in vivo. An analog of thalidomide.

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