Ampicillin suspension 125 mg 60 mL works by preventing the creation of a component necessary for bacterial cell wall formation. Thus stops the growth and multiplication of the microorganism.
Side effects
Major & minor side effects for Ampicillin suspension 125 mg 60 mL
Diarrhea severe
Skin rash severe
Fever with chills
Seizures
Fall in blood platelet levels
Fast/irregular heart beat
Abdominal pain rare
Abnormal liver function
Difficulty in breathing
Haemolytic anaemia rare
Mouth ulcers rare
Uses of Ampicillin suspension 125 mg 60 mL
What is it prescribed for?
Respiratory Tract Infection
Ampicillin suspension 125 mg 60 mL is used in the treatment of respiratory tract infections like pneumonia and brochitis, caused by Streptococcus pneumoniae and Staphylococcus aureus.
Urinary Tract Infection
Ampicillin suspension 125 mg 60 mL is used in the treatment of infections of the urinary tract caused by E.coli, Pseudomonas aeruginosa, Enterococci and Klebsiella pneumoniae.
Intra abdominal infection
This medicine is used in the treatment of Intraabdominal infections like gastroenteritis.
Shigellosis
This medicine is used to treat shigellosis, a bacterial infectious disease caused by a group of bacteria called Shigella and which is characterized by fever, abdominal cramps, and diarrhea.
Typhoid fever
This medicine is active against Salmonella typhi and used to treat typhoid fever.
Pneumonia
This medicine is used for the treatment of community-acquired pneumonia which is the most common type of lung infection caused by bacteria such as Streptococcus pneumoniae, Haemophilus Influenzae, Moraxella catarrhalis, etc.
Ear Infection (Otitis Media)
This medicine is used in the treatment of otitis media (middle ear infection) caused by bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, staphylococci, Streptococcus pyogenes, etc.
Concerns
Frequently asked questions
Onset of action
The peak effect of this medicine can be observed in 1 to 2 hours after an oral dose.
Duration of Effect
The effect of this medicine lasts for an average duration of 3 to 6 hours.
Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Is it habit forming?
No habit forming tendencies have been reported.
Usage in pregnancy?
This medicine is not known to cause any harm to the fetus. But the evidence is inadequate and it should be used only when necessary after consulting a doctor.
Usage while breast-feeding?
This medicine is safe to use during breastfeeding. Any incidence of rashes on skin or diarrhea in the infant should be reported. It is advised to consult a doctor before taking this medicine.
When not to use?
Allergy
Ampicillin suspension 125 mg 60 mL is not recommended if a patient is highly allergic to Ampicillin suspension 125 mg 60 mL or other antibiotics of Penicillins and Cephalosporins groups.
Warnings
Warnings for special population
Pregnancy
This medicine is not known to cause any harm to the fetus. But the evidence is inadequate and it should be used only when necessary after consulting a doctor.
Breast-feeding
This medicine is safe to use during breastfeeding. Any incidence of rashes on skin or diarrhea in the infant should be reported. It is advised to consult a doctor before taking this medicine.
General Warnings
Allergic Reaction
Avoid if you have a known allergy to Ampicillin suspension 125 mg 60 mL or Beta-lactam Antibiotics like penicillins and cephalosporins. Seek immediate medical attention if the patient experiences any allergic symptoms like rash, itching, nausea or vomiting, swelling of lips, hands, and feet.
Drug-resistance
Usage of Ampicillin suspension 125 mg 60 mL without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that is drug resistant.
Clostridium difficile-associated Diarrhea
Do not take if you experience severe diarrhea after receiving Ampicillin suspension 125 mg 60 mL. This is because the antibiotic therapy will cause an imbalance in the normal microbial flora in the large intestine, which promotes the growth of bacteria called clostridium difficile.
Mononucleosis
Ampicillin suspension 125 mg 60 mL is likely to cause rashes and bumps on the skin if the patient is suffering from Mononucleosis. Usage of Ampicillin suspension 125 mg 60 mL is not recommended in such cases.
Dosage
Missed Dose
The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it’s already time for your next scheduled dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of overdose.
Interactions
Interaction with Medicines
Atenolol moderate
Chloramphenicol moderate
Doxycycline moderate
Methotrexate severe
Warfarin moderate
Live cholera vaccine severe
Disease interactions
severe
This medicine should be used with caution in patients with a history of kidney diseases or active kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
moderate
This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient’s condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
The absorption of Ampicillin suspension 125 mg 60 mL may decrease in the presence of food. For proper absorption of the medicine, it should be taken at least 1 hour before or 2 hours after meals.
General Instructions
Take Ampicillin suspension 125 mg 60 mL 1 hour before or 2 hours after meals. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable effects. Do not stop taking Ampicillin suspension 125 mg 60 mL before completion of course.
Other details
To be taken on an empty stomach
To be taken as instructed by doctor
May cause sleepiness
References
practo.com –
Ampicillin [Internet].
Available from: https://www.practo.com/medicine-info/ampicillin-17-api
[cited 11 september 2019].
16 Nov 2017
dailymed.nlm.nih.gov –
Ampicillin [Internet].
Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=da8da9c0-fa46-40d3-82c6-1a18ffa1b585
[cited 11 september 2019].
April 16, 2010
medlineplus.gov –
Ampicillin Injection [Internet].
Available from: https://medlineplus.gov/druginfo/meds/a601133.html
[cited 11 september 2019].
22 August 2019
Additional Information:
How to use Ampicillin suspension 125 mg 60 mL
May be administered by direct IV push over 3-5 min at a rate not to exceed 100 mg/min or IV intermittent infusion over 15-30 min at concentration not to exceed 30 mg/mL.
Reconstitution: IM: Add (depending on manufacturer) 1.2 mL of SWFI or bacteriostatic water for injection to each 125 mg vial, 1 mL of diluent to each 250 mg vial, 1.8 mL of diluent to each 500 mg vial, 3.5 mL of diluent to each 1 gm vial, or 6.8 mL of diluents to each 2 gm vial. Intermittent infusion: Add 5 mL of SWFI or bacteriostatic water for injection to each 125, 250, or 500 mg vial or 7.4 to 10 mL of diluent to each 1 or 2 gm vial.
Compatibility: Stable in D5W, NS. At Y-site administration, incompatible with amphotericin B cholesteryl sulphate complex, epinephrine, fluconazole, hydralazine, midazolam, ondansetron, sargramostim, verapamil, vinorelbine. In syringe, incompatible with erythromycin lactobionate, gentamicin, hydromorphone, kanamycin, lincomycin, metoclopramide. When admixed, incompatible with amikacin, chlorpromazine, dopamine, gentamicin, hydralazine, prochlorperazine.
Stability: Solutions for IM or direct IV should be used within 1 hour. Solutions for IV infusion will be inactivated by dextrose at room temperature. If dextrose containing solutions are to be used, the resultant solution will only be stable for 2 hours versus 8 hours in NS. Stability of parenteral admixture in NS at room temperature (25?C) is 8 hours and at refrigeration (4?C) is 2 days.
what are the adverse effects of Ampicillin suspension 125 mg 60 mL?
Hypersensitivity, GI upset, rash, transient rise in liver enzymes. Rarely pseudomembranous colitis.
What happens if I miss a dose of Ampicillin suspension 125 mg 60 mL?
ORAL: Adults: 250 mg-1 gm every 6 hr. Children: 1 mth- 1 yr: 62.5 mg every 6 hr, the dose doubled in severe cases; 1-5 yr: 125 mg every 6 hr, the dose doubled in severe cases; 5-12 yr: 250 mg every 6 hr, the dose doubled in severe cases.
Urinary Tract Infection: Adults & Children over 10 yr, 500 mg every 8 hr, Children: Under 10 yr, half the adult dose.
Lower Respiratory Tract Infections: Adults & Children: gt; 20 kg: 250 mg every 6 hr. lt; 20 kg: 50 mg/kg/day divided as 6 hourly or 8 hourly dose.
Upper Respiratory Tract Infections: Adults & Children: gt; 20 kg: 250 mg every 6 hr. lt; 20 kg: 50 mg/kg/day divided as 6 hourly or 8 hourly dose.
INJECTION: Adults: 250-500 mg four to six times daily by IM or IV inj. Children: Half adult dose.
Meningitis: IV: Adults & Children: 150-200 mg/kg/day given every 3-4 hr.
Upper Respiratory Tract Infections: IM/IV: Adults & Children: gt; 40 kg: 250-500 mg every 8 hr. lt; 40 kg: 25-50 mg/kg every 6-8 hr.
Endocarditis (in combination with other antibiotic if necessary): By IV infusion: Adults: 2 gm every 6 hr, increased to 2 gm every 4 hr e.g. in enterococcal endocarditis or if ampicillin used alone.
One of the following licensed pharmacy from the nearest location will deliver Ampicillin suspension 125 mg 60 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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