Chromeceptin – 98%, high purity , CAS No.331859-86-0

in Lab Equipment
Sku: 1759789955-1125
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₦1,015,465.00

Pubchem Sid504762464 Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504762464 Canonical SmilesCN(C)C1=CC2=C(C=C1)C(C(=C(O2)N)C#N)C3=CC(=CC=C3)C(F)(F)F IUPAC Name2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile InChIKeyGVINXTXGDDSXFQ-UHFFFAOYSA-N INCHI1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3 Isomeric SMILES CN(C)C1=CC2=C(C=C1)C(C(=C(O2)N)C#N)C3=CC(=CC=C3)C(F)(F)F WGK Germany 3 Molecular Weight 359.35 Reaxy-Rn 11787426 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11787426&ln=
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Description

Chromeceptin is a cell-permeable benzochromene compound that blocks insulin-induced adipogenesis in 3T3-L1 cells (100% blockage at ? 20 ng/?l) and selectively suppresses IGF2- (insulin-like growth factor 2) dependent growth of HepG2 carcinoma cells (IC|50|= 29 nM). Chromeceptin has been shown to bind to MFP-2 (multifunctional protein-2) and activate STAT6-mediated gene expression, such as IGFBP-1 and SOCS-3, in HepG2 cells.

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