Bromopyruvic acid – 96%, high purity , CAS No.1113-59-3

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Sku: 1759817268-4909
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Pubchem Sid504754555 Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504754555 Canonical SmilesC(C(=O)C(=O)O)Br IUPAC Name3-bromo-2-oxopropanoic acid InChIKeyPRRZDZJYSJLDBS-UHFFFAOYSA-N INCHI1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7) Isomeric SMILES C(C(=O)C(=O)O)Br WGK Germany 3 RTECS UZ0840000 Molecular Weight 166.96 Beilstein 1746786 Reaxy-Rn 1746786 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1746786&ln=
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Description

3-Bromopyruvic acid is a brominated derivative of pyruvic acid , which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts.
Affinity label for cysteine residues; Cross-linker between nucleic acids and proteins

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