Colchicine – analytical standard??99%(HPLC), high purity , CAS No.64-86-8

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Sku: 1759817481-4931
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₦46,065.00

Canonical SmilesCC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC IUPAC NameN-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide InChIKeyIAKHMKGGTNLKSZ-INIZCTEOSA-N INCHI1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 Isomeric SMILES CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC WGK Germany 3 RTECS GH0700000 UN Number 1544 Packing Group I Molecular Weight 399.44 Beilstein 2228813 Reaxy-Rn 2228812 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2228812&ln=
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Description

Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis.

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