10-Hydroxycamptothecin

in Analytical
Sku: 1762988330-3042
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Product Info Cas No. 19685-09-7 Purity ?98% Formula C20H16N2O5 Formula Wt. 364.35 Chemical Name (S)-4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione IUPAC Name (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione Melting Point 268-270?C Solubility Soluble in DMSO (5 mg/mL), DMF, methanol. Insoluble in water. Appearance A pale yellow powder
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Description

10-Hydroxycamptothecin is a camptothecin derivative. Camptothecin is a quinolone alkaloid precursor of irinotecan; it is originally produced by Camptotheca. Camptothecin exhibits anticancer chemotherapeutic activity, inhibiting topoisomerase I and inducing double-stranded DNA breaks. Camptothecin is extremely cytotoxic and only its derivatives are clinically used as chemotherapeutics.

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