17-Allylaminogeldanamycin

in Analytical
Sku: 1762988281-3027
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₦487,050.00

Product Info Cas No. 75747-14-7 Purity ?97% Formula C31H43N3O8 Formula Wt. 585.69 IUPAC Name [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9, 15-tetramethyl-16,20, 22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12, 14,18-pentaen-10-yl] carbamate Synonym 17-(Allylamino)-17-desmethoxy-geldanamycin, allylaminogeldanamycin, 17-AAG, telatinib. Melting Point 200-205?C Solubility Soluble in DMSO or methanol. Appearance Purple powder
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Description

Geldanamycin derivative 17-AAG is an inhibitor of heat shock protein 90 (HSP90) that exhibits anti-inflammatory, anticancer chemotherapeutic, and antiviral activities. In endothelial cells, 17-AAG induces degradation of I?B?, attenuating NF-?B activation. 17-AAG induces Bax-dependent apoptosis in a variety of cancer models, both in vitro as well as in vivo. Additionally, 17-AAG inhibits replication of human cytomegalovirus.

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