5-Fluoro-2?-deoxyuridine – 99%, high purity , Thymidylate synthase inhibitor, CAS No.50-91-9, Thymidylate synthase inhibitor

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Sku: 1759818382-5010
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₦18,315.00

Pubchem Sid504750939 Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504750939 Canonical SmilesC1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)O IUPAC Name5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione InChIKeyODKNJVUHOIMIIZ-RRKCRQDMSA-N INCHI1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 Isomeric SMILES C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O RTECS YU7525000 UN Number 1760 Packing Group I Molecular Weight 246.19 Reaxy-Rn 24714617 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24714617&ln=
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Description

5-Fluoro-2?-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers.
5-Fluoro-2?-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.

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