6-Gingerol

6-Gingerol is originally found in species of Zingiber; it that exhibits antiemetic, antacid, anticancer, anti-inflammatory, anti-obesity, antihypertensive, anti-asthma, analgesic, and antinociceptive activities. 6-Gingerol inhibits 5-HT3 receptors and K2P 3.1 (TASK-1), K2P 9.1 (TASK-3), and K2P 18.1 (TRESK) K+ channels. 6-Gingerol also activates transient receptor potential vanilloid 1 (TRPV1) channels, decreasing allodynia and hyperalgesia in vivo. In other models, 6-gingerol inhibits the angiotensin II type 1 (AT-II) receptor, decreasing blood pressure. This compound also induces G2/M phase cell cycle arrest and apoptosis, inhibits mitochondrial respiration, increases oxidative stress and ROS production, and inhibits proliferation in myeloid leukemia cells. Additionally, 6-gingerol inhibits IL-1?-induced production of COX-2, NF-?B, IL-6, and IL-8, suppressing hepatic inflammation in vitro. 6-gingerol also inhibits rosiglitazone-induced adipogenesis, decreasing triglyceride levels and oil droplet sizes and downregulating expression of PPAR?. This compound also attenuates airway hyperresponsiveness in animal models.