7-O-Desmethyl Rapamycin is an impurity of rapamycin. Rapamycin is a macrolide initially produced by Streptomyces that exhibits immunosuppressive and pro-fibrotic activities. Rapamycin inhibits mTOR by binding FKBP12 and forming a complex that binds directly to mTOR; it is clinically used to prevent rejection in organ transplant patients. Rapamycin prevents IL-2-induced activation of T cells and B cells. Rapamycin also prevents IgA nephropathy, decreasing IgA deposition, inhibiting cell proliferation, and suppressing expression of ?-SMA, type III collagen, PDGF, and TGF-?1. Additionally, rapamycin increases connective tissue growth factor levels in epithelial cells.
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Uniformity of Dosage Units
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Uniformity of Dosage Units is a specialised analytical laboratory service that assesses whether individual dosage units contain sufficiently consis...
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