Abemaciclib mesylate

in Analytical
Sku: 1762987819-2880
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Product Info Cas No. 1231930-82-7 Purity ?98% Formula C27H32F2N8 ? CH4O3S Formula Wt. 602.71 Chemical Name N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate IUPAC Name N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;methanesulfonic acid Synonym LY2835219 methanesulfonate Solubility DMSO:84 mg/mL; Water:100 mg/mL Appearance White powder
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Description

Abemaciclib is a CDK4 and CDK6 inhibitor found to inhibit retinoblastoma phosphorylation, leading to G1/S arrest in ER+ breast cancer cells and to promote metabolic alterations in metastatic HR+ breast cancer cells.

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