Adryl100 ml

Adryl 100 mlDiphenhydramine is indicated for the treatment of followings: Seasonal, perennial, vasomotor rhinitis Urticaria, angioneurotic oedema, anaphylaxis Pruiritic conditions Premedication for emesis and motion sickness Miscellaneous like meniere's disease and parkinsonism Theropeutic ClassSedating Anti-histaminePharmacologyDiphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.Dosage & Administration of Adryl 100 mlAdult- Most allergic conditions: 25-50 mg three times a day with a further 50 mg at night. Children- 1 to 5 years of age: 5 mg i.e., 2.5 ml of elixir 4 times a day More than 6 years of age: 10 mg i.e. 5 ml of elixir 4 times a day Dosage of Adryl 100 mlAdult- Most allergic conditions: 25-50 mg three times a day with a further 50 mg at night. Children- 1 to 5 years of age: 5 mg i.e., 2.5 ml of elixir 4 times a day More than 6 years of age: 10 mg i.e. 5 ml of elixir 4 times a day Interaction of Adryl 100 mlDiphenhydramine administration significantly reduces the absorption of the antituberculous agent para-aminosalicyclic acid (PAS) from the gastrointestinal tract. CNS depressants may potentiate the sedative action of Diphenhydramine. Anticholinergic drugs may potentiate Diphenhydramine?s anticholinergic side effects.ContraindicationsKnown hypersensitivity to Adryl 100 ml, Ammonium chloride is contra-indicated in presence of impaired hepatic or renal function.Side Effects of Adryl 100 mlSide effect includes sedation, dizziness, tinnitus, fatigue, ataxia, blurred vision, diplopia, euphoria, and epigastric discomfort.Pregnancy & LactationCategory B: There are no adequate and well controlled studies in pregnant women using Adryl 100 ml. Therefore, Adryl 100 ml should be used in pregnancy only if clearly needed. Diphenhydramine hydrochloride has been reported to be excreted in breast milk and thus, use of Adryl 100 ml in lactating mother is not recommended.Precautions & WarningsCaution should be exercised with patients in whom drowsiness is undesirable e.g., drivers, machine operators. Concomitant consumption of alcohol or central nervous system (CNS) depressants will potentiate drowsiness.Overdose Effects of Adryl 100 mlSymptoms: Impaired consciousness? psychosis, seizures, antimuscarinic symptoms (e.g. mydriasis, tachycardia, tachyarrhythmias), resp failure, rhabdomyolysis; acute delirium with visual and auditory hallucination (topical). Management: Supportive and symptomatic treatment. Convulsions and marked CNS stimulation may be treated with IV diazepam.Storage ConditionsStore between 15-30? C. Protect from moisture.Drug ClassesSedating Anti-histamineMode Of ActionDiphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.PregnancyCategory B: There are no adequate and well controlled studies in pregnant women using Adryl 100 ml. Therefore, Adryl 100 ml should be used in pregnancy only if clearly needed. Diphenhydramine hydrochloride has been reported to be excreted in breast milk and thus, use of Adryl 100 ml in lactating mother is not recommended.