AEE-788

in Analytical
Sku: 1762987511-2817
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Product Info Cas No. 497839-62-0 Purity ?98% Formula C27H32N6 Formula Wt. 440.60 Chemical Name 6-{4-[(4-Ethyl-1-piperazinyl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-1H-pyrrolo[2,3-d]pyrimidin-4-amine IUPAC Name 6-{4-[(4-Ethyl-1-piperazinyl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-1H-pyrrolo[2,3-d]pyrimidin-4-amine Synonym AEE788, NVP-AEE788 Solubility 100mM in DMSO insoluble in ethanol and H2O
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Description

AEE-788 is an inhibitor of EGFR, HER2, VEGFR2, and FLT3 that exhibits anticancer chemotherapeutic activity. In animal models with ependymoma xenografts, AEE-788 increases survival rates. In acute myelogenous leukemia (AML) cells, AEE-788 inhibits cell proliferation and induces apoptosis. This compound displays mixed results in a clinical setting due to high toxicity.

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