Alsterpaullone

in Analytical
Sku: 1762987386-2778
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Product Info Cas No. 237430-03-4 Purity ?98% Formula C16H11N3O3 Formula Wt. 293.28 IUPAC Name 9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one Synonym 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one Solubility Soluble in DMSO. Appearance Yellow to Brown Powder
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Description

Alsterpaullone exhibits anticancer, anti-angiogenic, antiviral, and neuroprotective activities. Alsterpaullone inhibits cyclin-dependent kinases (CDKs), inducing G2/M phase cell cycle arrest and apoptosis in leukemia cells. Additionally, alsterpaullone inhibits glycogen synthase kinase 3 (GSK-3), inducing Wnt signaling; in ticks, this results in anti-fertility potential, decreasing egg hatching activity. Alsterpaullone also inhibits HIV-1 replication and proliferation. In ex vivo models of Alzheimer?s disease, this compound protects against neuronal death and decreases phosphorylation of tau protein.

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