Altrip6.25 mg

Altrip 6.25 mgAltrip 6.25 mg is prescribed to treat the acute headache phase of migraine attacks with or without aura. Altrip 6.25 mg is the only oral triptan approved in the USA for the treatment of migraine in adolescent from 12 to 17 years of age.Theropeutic Class5-HT AgonistsPharmacologyAltrip 6.25 mg is a selective and potent serotonin (5-hydroxytryptamine 1B/1D) agonist. Altrip 6.25 mg binds to specific serotonin receptors on meningeal arteries inhibiting the release of vasoactive peptides and causing constriction of the arteries. It has a limited effect on arteries supplying blood to the brain and little effect on cardiac and pulmonary vessels.Dosage & Administration of Altrip 6.25 mgAcute Treatment of Migraine Attacks: The recommended dose of Altrip 6.25 mg in adults and adolescents age 12 to 17 years is 6.25 mg to 12.5 mg, with the 12.5 mg dose tending to be a more effective dose in adults. If the headache is relieved after the initial Altrip 6.25 mg malate dose but returns, the dose may be repeated after 2 hours. The maximum daily dose should not exceed 25 mg. The safety of treating an average of more than four migraines in a 30-day period has not been established.Hepatic Impairment: The recommended starting dose of Altrip 6.25 mg malate in patients with hepatic impairment is 6.25 mg. The maximum daily dose should not exceed 12.5 mg over a 24-hour periodRenal Impairment: The recommended starting dose of Altrip 6.25 mg malate in patients with severe renal impairment is 6.25 mg. The maximum daily dose should not exceed 12.5 mg over a 24-hour periodDosage of Altrip 6.25 mgAcute Treatment of Migraine Attacks: The recommended dose of Altrip 6.25 mg in adults and adolescents age 12 to 17 years is 6.25 mg to 12.5 mg, with the 12.5 mg dose tending to be a more effective dose in adults. If the headache is relieved after the initial Altrip 6.25 mg malate dose but returns, the dose may be repeated after 2 hours. The maximum daily dose should not exceed 25 mg. The safety of treating an average of more than four migraines in a 30-day period has not been established.Hepatic Impairment: The recommended starting dose of Altrip 6.25 mg malate in patients with hepatic impairment is 6.25 mg. The maximum daily dose should not exceed 12.5 mg over a 24-hour periodRenal Impairment: The recommended starting dose of Altrip 6.25 mg malate in patients with severe renal impairment is 6.25 mg. The maximum daily dose should not exceed 12.5 mg over a 24-hour periodInteraction of Altrip 6.25 mgThese drugs have been reported to cause prolonged vasospastic reactions. Cases of life-threatening serotonin syndrome have been reported during combined use of triptans and selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs).ContraindicationsAs with other 5-HT1B/1D receptor agonists, Altrip 6.25 mg should not be used in patients with a history, symptoms or signs of ischaemic heart disease (myocardial infarction, angina pectoris, documented silent ischaemia, Prinzmetal's angina) or severe hypertension and uncontrolled mild or moderate hypertension. Concomitant administration with ergotamine, ergotamine derivatives (including methysergide) and other 5-HT1B/1D agonists is contraindicated.Side Effects of Altrip 6.25 mgSerious cardiac reactions, including myocardial infarction, have occurred following the use of Altrip 6.25 mg malate Tablets. These reactions are extremely rare and most have been reported in patients with risk factors predictive of CAD (Coronary Artery Disease).Pregnancy & LactationPregnancy Category C. There is no data regarding excretion of Altrip 6.25 mg in human milk.Precautions & WarningsHypersensitivity to the active substance or to any of the excipients. Patients with severe hepatic impairment, with a previous cerebrovascular accident (CVA) or transient ischaemic attack (TIA) Peripheral vascular disease.Storage ConditionsKeep below 30? C temperature in a dry place. Protected from light. Do not freeze. Keep out of the reach of children.Drug Classes5-HT AgonistsMode Of ActionAltrip 6.25 mg is a selective and potent serotonin (5-hydroxytryptamine 1B/1D) agonist. Altrip 6.25 mg binds to specific serotonin receptors on meningeal arteries inhibiting the release of vasoactive peptides and causing constriction of the arteries. It has a limited effect on arteries supplying blood to the brain and little effect on cardiac and pulmonary vessels.PregnancyPregnancy Category C. There is no data regarding excretion of Altrip 6.25 mg in human milk.