AMG-458

in Analytical
Sku: 1762987326-2757
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Product Info Cas No. 913376-83-7 Purity ?98% Formula C30H29N5O5 Formula Wt. 539.58 Chemical Name 1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yl)oxypyridin-2-yl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide IUPAC Name 1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yl)oxypyridin-2-yl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide Synonym AMG458 Solubility DMSO 21 mg/mL (38.91 mM) Water Insoluble Ethanol Insoluble Appearance White Crystal Powder
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Description

AMG-458 is an inhibitor of c-MET that exhibits anticancer chemotherapeutic activity. AMG-458 enhances the radiosensitivity of lung adenocarcinoma cells, decreasing activation of Akt and ERK and inducing apoptosis. In vivo, this compound inhibits the growth of glioblastoma tumors.

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