Amiloride Hydrochloride Dihydrate

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Sku: 1762987316-2753
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Product Info Cas No. 17440-83-4 Purity ?98% Formula C6H8ClN7O ? HCl ? 2H2O Formula Wt. 302.12 Chemical Name 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazine-carboxamide hydrochloride IUPAC Name 3, 5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; dihydrate;hydrochloride Synonym N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride, Amiprazidine Melting Point 285-288?C Solubility Soluble in water. Appearance Light yellow crystalline powder
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Description

Amiloride is a potassium-sparing diuretic that exhibits antihypertensive and antiviral activities. Amiloride inhibits epithelial Na+ channels (ENaCs), acid-sensing ion channels, and Na+/H+ antiporters. Amiloride prevents Na+ reabsorption in the kidney, increasing excretion of Na+ and water; it is clinically used to treat hypertension and congestive heart failure (CHF). In vitro, amiloride inhibits replication of Coxsackievirus B3 and poliovirus type 1.

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