Amyloid-? (25-35)

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Sku: 1762987208-2726
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Product Info Cas No. 131602-53-4 Purity ?95% Formula C45H81N13O14S Formula Wt. 1060.27 IUPAC Name 2-[[2-[[2-[[2-[[2-[2-[[2-[[6-amino-2-[[4-amino-2-[[2-[(2-aminoacetyl) amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino] acetyl]amino]propanoylamino]-3-methylpentanoyl]amino]-3-methylpentanoyl] amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid Synonym Amyloid-beta protein fragment (25-35) Solubility Soluble in water (~6mg/mL). Not directly soluble in buffer or saline. Appearance White to off white powder
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Description

Amyloid-? (A?) is a peptide cleavage product of amyloid precursor protein (APP) that is often used as a biomarker in Alzheimer?s disease. Misfolded A? oligomers instigate conformation changes in other, normally folded A? oligomers, increasing the number of misfolded proteins and eventually forming neurotoxic plaques. These plaques impair cognitive performance in vivo.

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