Ascomycin

in Analytical
Sku: 1762986769-2663
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₦544,170.00

Product Info Cas No. 104987-12-4 Purity ?98% Formula C43H69NO12 Formula Wt. 792.01 IUPAC Name (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone Synonym Immunomycin Melting Point 162-163?C Solubility Soluble in DMSO Appearance White Powder
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Description

Ascomycin is an ethyl analog of FK506 that was initially produced by species of Streptomyces. Ascomycin binds FK506 binding protein 12 and the resulting complex inhibits calcineurin/protein phosphatase 2B (PP2B), altering peptidyl-prolyl isomerase activity of the enzyme. Ascomycin exhibits immunosuppressive, anti-inflammatory, and anticonvulsant activities. Clinically, ascomycin is used to treat organ transplant rejection and inflammatory skin diseases.

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