Atorvastatin Calcium Trihydrate

Name: Atorvastatin Calcium Trihydrate
SKU: 1762986704-2643
Availability: InStock

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Sku: 1762986704-2643

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Features

Product Info Cas No. 344423-98-9 Purity ?98% Formula (C33H34FN2O5)2Ca ? 3H2O Formula Wt. 1209.39 Chemical Name (?R,?R)-2-(4-Fluorophenyl)-?,?-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid IUPAC Name calcium;7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2- ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;trihydrate Synonym Atorvastatin Calcium Salt, Lipitor, Sortis: Torvast, Totalip, Xarator Melting Point 159-161?C Solubility Soluble in methanol. Very slightly soluble in water and acetonitrile. Slightly soluble in ethanol. DMSO (10 mg/ml) Appearance Off White Powder

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Description

Description

Atorvastatin exhibits anti-hyperlipidemic, anti-inflammatory, anti-fibrotic, and cardioprotective activities. Atorvastatin acts as an inhibitor of HMG-CoA reductase, preventing cholesterol synthesis and decreasing levels of total cholesterol, triglycerides, and LDL and increasing levels of HDL. In animal models of renal ischemia/perfusion, atorvastatin decreases expression of toll-like receptor 4 (TLR4) an hmgb1, decreasing oxidative stress and inflammation. Additionally, atorvastatin inhibits left ventricular hypertrophy and cardiac fibrosis and decreases expression of HSP47 in animal models of heart failure.

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