AZD-9291

in Analytical
Sku: 1762986542-2602
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Product Info Cas No. 1421373-65-0 Purity ?99% Formula C28H33N7O2 Formula Wt. 499.62 IUPAC Name N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}phenyl)acrylamide Synonym AZD 9291, AZD9291, Osimertinib, Mereletinib
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Description

AZD-9291 is an irreversible inhibitor of EGFR. It is approved for the treatment of metastatic EGFR T790M mutation-positive non-small cell lung cancer (NSCLC) in patients failing previous tyrosine kinase therapy, and more recently also in T790M negative NSCLC patients. Combination therapy with pemetrexed and cisplatin is currently being studied to delay or overcome resistance to AZD-9291 that is commonly experienced by patients after prolonged treatment.

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