Azelastine Hydrochloride

in Analytical
Sku: 1762986523-2598
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Product Info Cas No. 79307-93-0 Purity ?98% Formula C22H23N3O ? HCl Formula Wt. 418.35 Chemical Name 4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl- 1H-azepin-4-yl)-1(2H)-phthalazinone hydrochloroide IUPAC Name 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one; hydrochloride Synonym Allergodil, Astelin, Azeptin, Optilast, Rhinolast Melting Point 225-229?C Solubility Slightly soluble in ethanol, octanol or glycerine. Appearance White Crystalline Powder
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Description

Azelastine is a second generation antihistamine that inhibits H1 histamine receptors. Azelastine exhibits anti-allergic, anti-inflammatory, and anti-tussive activities and is clinically used to treat allergic rhinitis. Azelastine activates transient receptor potential vanilloid 1 (TRPV1) channels, inducing desensitization. In mast cells, azelastine inhibits production of TNF-?, IL-6, and IL-8 and suppresses activation of NF-?B. Additionally, this compound decreases capsaicin-induced cough in vivo.

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