Benidipine Hydrochloride

in Analytical
Sku: 1762986339-2558
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Product Info Cas No. 91599-74-5 Purity ?98% Formula C28H31N3O6 ?HCl Formula Wt. 542.03 Chemical Name 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride IUPAC Name (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1) Synonym KW-3049 Solubility DMSO Solubility: 8 mg/mL (14.75 mM) Appearance Yellow crystalline powder
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Description

Benidipine is a long-lasting dihydropyridine calcium channel blocker. Its antihypertensive activity involves the inhibition of Ca(2+) influx through L-type voltage dependent calcium channels and the ability to restore endothelial function. It prevents lysoPC-induced caspase-3 activation through stimulation of NO release thereby exerts its anti-apoptosis action on endothelial cells. Benidipine increases the maximal activity of ERK1/2 but has no significant effect on p38 MAPK, decreases mitochondrial cytochrome c release, and reduces caspase-9 activation.

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