Betamethasone Valerate

Name: Betamethasone Valerate
SKU: 1762986286-2539
Availability: InStock

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Sku: 1762986286-2539

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Features

Product Info Cas No. 2152-44-5 Purity ?98% Formula C27H37FO6 Formula Wt. 476.58 Chemical Name [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate IUPAC Name [(8S,9R,10S,11S,13S,14S,16S, 17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13, 16-trimethyl-3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate Synonym Betaderm, Betnovate Melting Point 183.5?C Solubility Insoluble in water. Ethanol (62 mg/mL). Soluble in acetone, DMSO. Appearance White to off white powder

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Description

Description

Betamethasone valerate (BMV) is a synthetic glucocorticoid that is commonly used to treat psoriasis and dermatitis. BMV exhibits immunomodulatory, anti-inflammatory, and vasoconstrictive activity in vitro and in vivo. Across animal models of varying ages, BMV impairs maturation and viability of Langerhans and epidermal cells. BMV also decreases endogenous phospholipase activity and inhibits vasodilatory responses in skin; this partial vasoconstriction decreases blood flow, often resulting in a decrease in local TGF-?1 levels.

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