Big endothelin-1 is a cleavage precursor to endothelin-1; secretion of this peptide is stimulated by angiotensin II (AT II) and thrombin. Like endothelin-1, big endothelin-1 exhibits vasoconstrictive/hypertensive activity, increasing arteriolar constriction and decreasing blood flow.
Uniformity of Dosage Units
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Uniformity of Dosage Units is a specialised analytical laboratory service that assesses whether individual dosage units contain sufficiently consis...



































