BLU-667

in Analytical
Sku: 1762986170-2509
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Product Info Cas No. 2097132-94-8 Purity ?98% Formula C27H32FN9O2 Formula Wt. 533.61 IUPAC Name trans-N-{(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)-3-pyridinyl]ethyl}-1-methoxy-4-{4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}cyclohexanecarboxamide Synonym BLU 667, BLU667, Pralsetinib
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Description

BLU-667 is an inhibitor of the rearranged during transfection (RET) kinase. RET is an oncogenic driver activated in multiple cancers. BLU-667 is an early selective small molecule designed to target RET, in contrast with current treatment methods that have been limited to multikinase inhibitors. BLU-667 potently inhibits growth of RET-driven non-small cell lung cancer and thyroid cancer xenografts in vtiro.

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