BLZ-945

in Analytical
Sku: 1762986162-2506
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Product Info Cas No. 953769-46-5 Purity ?95% Formula C20H22N4O3S Formula Wt. 398.48 Chemical Name 4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methyl-2-pyridinecarboxamide IUPAC Name 4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methyl-2-pyridinecarboxamide Synonym BLZ945 Solubility Soluble in DMSO. Slightly soluble in ethanol. Insoluble in water. Appearance Pale yellow solid.
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Description

BLZ945 is an inhibitor of the CSF-1R kinase receptor; it exhibits immunostimulatory and anticancer chemotherapeutic activities and prevents skeletal metastasis of diseases. BLZ945 prevents turnover of tumor-associated macrophages and increases CD8+ T cell levels, limiting tumor growth in animal models of mammary carcinogenesis.

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