Bromosporine

in Analytical
Sku: 1762986066-2470
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Product Info Cas No. 1619994-69-2 Purity ?99% Formula C17H20N6O4S Formula Wt. 404.44 Chemical Name ethyl N-[6-[3-(methanesulfonamido)-4-methylphenyl]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate IUPAC Name ethyl N-[6-[3-(methanesulfonamido)-4-methylphenyl]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate Synonym N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate; GTPL8234 Solubility DMSO 81 mg/mL (200.27 mM) Water Insoluble Ethanol Insoluble Appearance White to off white powder
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Description

Bromosporine is an inhibitor of BET bromodomains (BRDs) BRD2, BRD4, BRD9, and CECR2; it may exhibit anticancer potential. It has been found to have a synergistic effect with 5-fluorouracil against colorectal cancer cells. Bromosporine is also effective with in vitro studies in reactivating latent HIV-1 reservoirs in order to eradicate the disease through a ?shock and kill? strategy.

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