Cytotrexate tablet 10 mg 10?s

Cytotrexate tablet 10 mg 10?s works by interfering the DNA synthesis and stops the growth of the cells.
Side effects
Major & minor side effects for Cytotrexate tablet 10 mg 10?s

Diarrhea severe

Joint pain severe

Abdominal pain severe

Swelling of feet or lower legs severe

Dizziness severe

Fever with chills severe

Unusual bleeding severe

Blurred vision severe

Temporary Hair Loss

Loss of appetite

Nausea or Vomiting

Pale skin

Skin rash

Uses of Cytotrexate tablet 10 mg 10?s
What is it prescribed for?

Acute Lymphoblastic Leukemia
Cytotrexate tablet 10 mg 10?s is used in the treatment of cancer of the bone marrow that affects the production of white blood cells.

Choriocarcinoma
Cytotrexate tablet 10 mg 10?s is used in the treatment of cancer of the women’s uterus.

Meningeal Leukemia
Cytotrexate tablet 10 mg 10?s is used in the treatment of cancer meningitis which is a thin layer that protects the brain and spinal cord.

Breast cancer
Cytotrexate tablet 10 mg 10?s is used with other medications in the treatment of breast cancer.

Rheumatoid Arthritis
Cytotrexate tablet 10 mg 10?s is used to relieve the symptoms of inflammation in rheumatoid arthritis.

Psoriasis
Cytotrexate tablet 10 mg 10?s is used in the treatment of psoriasis which is an autoimmune skin disease.

Concerns

Frequently asked questions

Onset of action
The effect of this medicine can be observed in 1 to 2 hours after an oral dose and 30 to 60 minutes after an intramuscular injection.

Duration of Effect
The effect of this medicine lasts for an average duration of 9 to 30 hours at a low dose and 24 to 45 hours at a high dose.

Safe with Alchohol?
Consumption of alcohol is not recommended due to the risk of liver injury. Close monitoring of liver enzymes is necessary. Seek immediate medical treatment if any symptoms like lethargy, yellow colored eyes, and skin, abdominal pain appear.

Is it habit forming?
No habit forming tendencies were reported.

Usage in pregnancy?
This medicine is not recommended for pregnant women.

Usage while breast-feeding?
This medicine is not recommended in breastfeeding women.

When not to use?

Allergy
Not recommended in patients with known allergy to Cytotrexate tablet 10 mg 10?s .

Pregnancy
Not recommended for pregnant women due to the risk of birth defects.

Liver disease
Not recommended in patients with the existing liver disease.

Blood disorder
Not recommended in patients with existing blood diseases.

Warnings

Warnings for special population

Pregnancy
This medicine is not recommended for pregnant women.

Breast-feeding
This medicine is not recommended in breastfeeding women.

General Warnings

Liver injury
This medicine is not recommended in the patients with the liver injury. The concentration of this medicine may increase in these patients. The baseline of the liver function tests should be obtained before starting the treatment.

Kidney injury
This medicine is not recommended in the patients with the kidney injury. It may cause kidney injury at higher doses. The dose of this medicine should be adjusted based on the CrCl.

Lung toxicity
This medicine may cause severe lung injuries like pulmonary fibrosis, pulmonary interstitial infiltrates. Any symptoms of breathing difficulty and signs of lung impairment should be informed to the doctor. The treatment should be discontinued if any symptoms appear.

Blood cell count
This medicine may lower the white blood cell count (neutrophils) and platelets. Close monitoring of blood cell count is necessary. The baseline of the blood cell count should be obtained before initiation of the treatment. Do not start the treatment if the counts are less.

Skin reactions
The medicine may cause severe skin reactions stevens-johnson syndrome, skin necrosis, and skin ulceration. Inform the doctor if any symptoms appear. The treatment should be discontinued.

Gastrointestinal injury
This medicine is not recommended for use in patients with gastrointestinal disorders like diarrhea and ulcerative stomatitis. Inform the doctor if you have any gastrointestinal disorders before initiation of the therapy.

Infections
The chances of occurring infections are more in the patients receiving this medicine. Hold the chemotherapy and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

Dosage

Missed Dose
It is advised not to miss any dose. If you missed any dose, you should contact your doctor immediately.

Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions
Interaction with Medicines

Azole antifungal agents moderate

Atorvastatin moderate

Live vaccines severe

Proton pump inhibitors severe

Disease interactions

severe
Cytotrexate tablet 10 mg 10?s is not recommended for the treatment of psoriasis and rheumatoid arthritis in patients with liver disease. The baseline of the liver enzymes should be obtained before starting the therapy. The treatment should be discontinued if liver enzymes are elevated.

General Instructions

Take Cytotrexate tablet 10 mg 10?s as instructed by your doctor. Do not take in larger amounts than advised. Do not miss any scheduled dose. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.

Other details

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

References

practo.com –
Methotrexate [Internet].
Available from: https://www.practo.com/medicine-info/methotrexate-177-api
[cited 4 octotber 2019].
16 Nov 2017

medlineplus.gov –
Methotrexate [Internet].
Available from: https://medlineplus.gov/druginfo/meds/a682019.html
[cited 4 octotber 2019].
01 October 2019

dailymed.nlm.nih.gov –
Methotrexate [Internet].
Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ec476b11-0b3c-4139-b1eb-a3daa76bc271#a15d5648-439e-4a6d-b23d-1c02c0329aff
[cited 4 octotber 2019].
April 1, 2016