K252a

in Analytical
Sku: 1762981071-1469
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Product Info Cas No. 99533-80-9 Purity ?98% Formula C27H21N3O5 Formula Wt. 467.48 IUPAC Name methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate Synonym SF 2370 Melting Point 262-263?C Solubility Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine; soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; insoluble in water, 2-propanol Appearance White Powder
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Description

K252a is an aglycone analog of staurosporine that acts as a protein kinase inhibitor, inhibiting PKC. K252a also inhibits TrkA/B receptors, suppressing activity of neurotrophins such as nerve growth factor (NGF).

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