? Melanocyte-stimulating hormone (?-MSH) is an endogenous POMC-derived peptide in the pituitary involved in energy homeostasis and melanin production that activates melanocortin receptors. ?-MSH exhibits anti-inflammatory, neuroprotective, cognition enhancing, anxiolytic, and antioxidative activities. In vivo, ?-MSH decreases the intensity of acetaminophen-induced liver lesions. In animal models of Alzheimer?s disease, ?-MSH prevents loss of GABAergic neurons, decreases anxiety levels, and improves spatial memory. ?-MSH also decrease apoptosis and oxidative stress in diabetic retinas by inhibiting upregulation of Foxo4 induced by glucose.
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Uniformity of Dosage Units
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Uniformity of Dosage Units is a specialised analytical laboratory service that assesses whether individual dosage units contain sufficiently consis...
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