?-Naphthoflavone is an agonist at the aryl hydrocarbon receptor and an inducer of phase II enzymes. ?-Naphthoflavone exhibits anticancer and chemopreventive activities but also displays tumor-promoting activity in other models. In animal models, ?-naphthoflavone inhibits cigarette smoke-induced DNA damage and tumor development. In breast cancer cells, this compound induces G0/G1 phase cell cycle arrest, downregulates expression of cyclin D1, cyclin D3, and CDK4, upregulates expression of p21, inhibits PI3K/Akt signaling, and activates MAPK/ERK signaling.
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Uniformity of Dosage Units
Allschoolabs
Uniformity of Dosage Units is a specialised analytical laboratory service that assesses whether individual dosage units contain sufficiently consis...
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