(S,S)-ICG-001 is an inhibitor of Wnt/?-catenin signaling. Treatment of nasopharyngeal carcinoma cells with ICG-001 led to reduced capability of the cells to adhere to extracellular matrix and capillary endothelial cells, and reduced tumor cell migration and invasion. In high-fat diet mice, treatment improved renal function, inhibited proinflammatory cytokines expression, reduced proteinuria and alleviated podocyte injury. Treatment of cancer stem-like cells with both ICG-001 and metformin together led to decreased expression of CSC markers and promoted autophagy and apoptosis synergistically.
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Uniformity of Dosage Units
Allschoolabs
Uniformity of Dosage Units is a specialised analytical laboratory service that assesses whether individual dosage units contain sufficiently consis...
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