Tadalafil , 50 MG

Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50?= 1.2 nM).1?It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 ?M), however, it does also inhibit PDE11 (IC50?= 11 nM).?In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-?, IL-1?, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury.2?It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice.3?Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.Formal Name(6R)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12aR-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dioneCAS Number171596-29-5Molecular FormulaC22H19N3O4Formula Weight389.4Product More SpecificationsSpecificationPurity?98%FormulationA crystalline solidSolubility(Learn about Variance in Solubility)DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlmax221, 284, 292 nmSMILESO=C1N(C)CC(N2[C@H](C3=CC=C(OCO4)C4=C3)C5=C(C6=CC=CC=C6N5)C[C@@]21[H])=OInChi CodeInChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1InChi KeyWOXKDUGGOYFFRN-IIBYNOLFSA-NStorage-20?CMade InUSAThere are no reviews for this product.Write a review Your Name Your ReviewNote: HTML is not translated! Rating Bad Good Captcha Please complete the captcha validation below Continue