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A-Calm 50 mgA-Calm 50 mg is indicated in- Treatment of increased tone of skeletal muscles due to organic neurological disorders (injury of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis). Treatment of muscular spasm, muscular contracture, rigidity, spinal automatism. ... Read moreA-Calm 50 mg is indicated in- Treatment of increased tone of skeletal muscles due to organic neurological disorders (injury of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis). Treatment of muscular spasm, muscular contracture, rigidity, spinal automatism. In the treatment of vascular diseases (Obliterative arteriosclerosis, diabetic angiopathy, obliterative thromboangitis, Raynaud's disease, diffuse scleroderma). In individual cases, post-thrombotic venous and lymphatic circulation disorders and crural ulcer. Theropeutic ClassCentral Depolarizing muscle relaxants, Centrally acting Skeletal Muscle RelaxantsPharmacologyTolperisone is a centrally acting muscle relaxant that acts at the reticular formation in the brain stem by blocking voltage-gated sodium and calcium channelsDosage & Administration of A-Calm 50 mgAdult: 150-450 mg daily, administered in 2 or 3 divided doses. The maximum dosage is 450 mg/day.Children: 3 months to 6 years: 1-2 mg/kg/day in 3 divided doses. 6 years to 14 years: 2-4 mg/kg/day in 3 divided doses Dosage of A-Calm 50 mgThe recommended dose is as follows: Adult: 50-150 mg three times daily according to the individual requirement and tolerance of the patient. Children (from 3 months to 6 years): 5 mg/kg/day in three divided doses. Children (from 6 to 14 years): 2-4 mg/kg/day in three divided doses. or, as directed by the registered physician. Interaction of A-Calm 50 mgConcomitant use of methocarbamol with A-Calm 50 mg has been reported to cause disturbance of visual accommodation.ContraindicationsIt is contraindicated in patients with a history of hypersensitivity to any component of the product, myasthenia gravis and nursing mother.Side Effects of A-Calm 50 mgPossible side-effects include sometimes muscular weakness, headache, nausea, vomiting and rarely hypersensitivity reactions (itching, redness of the skin, skin rash) may occur.Pregnancy & LactationA-Calm 50 mg should be used in pregnancy according to physician's advice. Tolperisone hydrochloride should not be used during breast-feeding.Precautions & WarningsIn case of children, the prescribed dose and duration of treatment should closely be observed.Overdose Effects of A-Calm 50 mgExcitability has been noted after ingestion of high doses by children. In suicide studies of three isolated cases, it is believed that ingestion of tolperisone was the cause of death.Storage ConditionsKeep below 30?C temperature, away from light & moisture. Keep out of the reach of children.Drug ClassesCentral Depolarizing muscle relaxants, Centrally acting Skeletal Muscle RelaxantsMode Of ActionA-Calm 50 mg is a centrally acting muscle relaxant, which acts on the central nervous system and used mainly for the treatment of elevated muscle tone and tension as well as for certain circulation problems in the extremities.PregnancyA-Calm 50 mg should be used in pregnancy according to the physician's advice. It should not be used during breast feeding.

A-Flox 500 mgA-Flox 500 mg is indicated for the treatment of infections caused by Gram-positive organisms, including those resulting from penicillinase-producing staphylococci. These indications encompass a wide range of conditions: Skin and Soft Tissue Infections: This includes boils, abscesses, carbuncles, and various infected skin conditions such as ulcers, eczema, acne, furunculosis, cellulitis, as well as infected wounds and burns. Respiratory Tract Infections: Flucloxacillin is effective against pneumonia, lung abscesses, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy. Other Infections: It is also utilized for treating osteomyelitis, enteritis, endocarditis, urinary tract infections, meningitis, and septicaemia caused by organisms sensitive to A-Flox 500 mg. Prophylactic Use: In addition, it serves as a prophylactic agent during major surgical procedures, particularly in cardiothoracic and orthopedic surgery when deemed appropriate.Theropeutic ClassPenicillinase-resistant penicillinsPharmacologyFlucloxacillin is effective against Gram-positive organisms, including those that produce penicillinase. It exhibits limited activity against Gram-negative bacilli. The mode of action of Flucloxacillin involves the inhibition of bacterial cell wall formation. As an isoxazolyl penicillin, Flucloxacillin combines key properties such as resistance to penicillinase hydrolysis, stability in gastric acid conditions, and activity against Gram-positive bacteria. This bactericidal antibiotic is particularly valuable in combating penicillinase-producing staphylococci. Flucloxacillin works by disrupting peptidoglycan synthesis, a vital component of the bacterial cell wall that provides mechanical stability. In the final step of peptidoglycan synthesis, Flucloxacillin inhibits the transpeptidase enzyme responsible for cross-linking, specifically preventing the linkage of the terminal glycine residue to the fourth residue of the pentapeptide (D-alanine). The bacterial cell wall weakens, leading to swelling and eventual rupture. Flucloxacillin's resistance to bacterial penicillinase likely arises from steric hindrance induced by its acyl side chain, preventing the opening of the ?-lactam ring.Dosage of A-Flox 500 mgOral Administration: Adults: Take 250 mg four times a day. The dosage may be doubled in severe infections. For osteomyelitis and endocarditis, a daily dose of up to 8 grams is administered in 6-8 hourly divided doses. Children (2-10 years): Use half of the adult dose. Children (Under 2 years): Use a quarter of the adult dose. Parenteral Administration: Adults or Elderly: Intramuscular Injection: Take 250 mg four times daily. Intravenous Injection: Administer 250 mg to 1 gram four times daily, either through slow injection over 3 to 4 minutes or by intravenous infusion. In severe infections, all systemic doses can be doubled, with doses of up to 8 grams daily suggested for endocarditis or osteomyelitis. Children: For children aged 2-10 years, use half of the adult dose. For children under 2 years, use a quarter of the adult dose. Administration of A-Flox 500 mgOral doses should be administered 1 hour before meal.Interaction of A-Flox 500 mgFor severe renal failure (creatinine clearance <10 ml/min), it is advisable to contemplate a dose reduction or an extension of the dosing interval.ContraindicationsA-Flox 500 mg is contraindicated in penicillin hypersensitive patients.Side Effects of A-Flox 500 mgCommon side effects affecting the gastrointestinal tract include nausea, vomiting, diarrhea, dyspepsia, and other minor gastrointestinal disturbances. Reports have indicated occurrences of rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice.Precautions & WarningsExercise caution when administering A-Flox 500 mg to patients exhibiting signs of liver dysfunction.?Additionally, be cautious when treating patients with an allergic predisposition.Storage ConditionsKeep in a dry place away from light and heat. Keep out of the reach of children.Use In Special PopulationsFor severe renal failure (creatinine clearance <10 ml/min), it is advisable to contemplate a dose reduction or an extension of the dosing interval.ReconstitutionA-Flox 500 mg has been employed through alternative administration routes in combination with systemic therapy. It has been dosed at 250 mg to 500 mg per day via intra-articular injection, potentially dissolved in a 0.5% solution of lignocaine hydrochloride, as well as through intrapleural injection at a daily dosage of 250 mg. Using the powder for injection, 125 mg to 250 mg has been dissolved in 3 ml of sterile water and administered via nebulizer four times daily.Drug ClassesPenicillinase-resistant penicillinsMode Of ActionFlucloxacillin exhibits activity against Gram-positive organisms, including strains that produce penicillinase. Its efficacy against Gram-negative bacilli is limited. The mechanism of action involves the inhibition of bacterial cell wall formation. Flucloxacillin, classified as an isoxazolyl penicillin, possesses unique qualities such as resistance to hydrolysis by penicillinase, stability in gastric acid conditions, and effectiveness against Gram-positive bacteria. This bactericidal antibiotic is particularly valuable in combatting penicillinase-producing staphylococci. Flucloxacillin disrupts bacterial cell wall synthesis, specifically interfering with peptidoglycan production. Peptidoglycan is a complex structure that provides mechanical stability to the cell wall. The final step in peptidoglycan synthesis, which involves cross-linking with the terminal glycine residue of the pentaglycin bridge connecting to the fourth residue of the pentapeptide (D-alanine), is hindered by Flucloxacillin. Consequently, the bacterial cell wall weakens, leading to cell swelling and eventual rupture. Flucloxacillin's resistance to bacterial penicillinase is likely attributed to steric hindrance caused by its acyl side chain, preventing the opening of the ?-lactam ring.PregnancyThe US FDA Pregnancy Category for A-Flox 500 mg is B. There are no adequate and well-controlled studies conducted in pregnant women. Since animal reproduction studies may not always accurately predict human responses, it is advisable to use this medication during pregnancy only when it is clearly necessary. A-Flox 500 mg has been demonstrated to be excreted in human milk, so caution should be exercised when administering it to a lactating mother.Pediatric UsesIn severe renal failure (creatinine clearance <10 ml/min), a reduction in dose or an extension of dose interval should be considered.