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Esomeprazole?is used to treat certain?stomach?and?esophagus?problems (such as?acid reflux, ulcers). It works by decreasing the amount of acid your?stomach?makes. It relieves symptoms such as?heartburn, difficulty swallowing, and persistent?cough. This?medication?helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent?cancer?of the esophagus. Esomeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).