INTRODUCTION
DORLAX 5MG TABLET contains Bisoprolol which belongs to a group of medicines called Beta- blockers. It is used to treat stable heart failure in combination with other medicines. Stable heart failure is a condition in which patients of heart failure are receiving medication and show no physical symptoms suggestive of worsening of the condition.
DORLAX 5MG TABLET is used to treat high blood pressure (Hypertension) and angina pectoris (Chest pain). Hypertension is defined as persistently elevated arterial blood pressure and Angina is a type of chest pain which is caused by reduced blood flow to the heart as a result of coronary artery disease. Symptoms are feeling pressure, squeezing, heaviness, tightness or pain in the chest or a heavy weight is lying on the chest.
DORLAX 5MG TABLET is not recommended for use in patients having heart and severe lung diseases, impaired blood supply of the arms and legs (peripheral arterial occlusive disease), severe blood circulation problem in limbs (Raynaud?s syndrome), untreated pheochromocytoma, metabolic acidosis, low blood pressure (Hypotension).
Before taking DORLAX 5MG TABLET, inform your doctor, if you have severe kidney or liver diseases, diabetes, are on strict fasting, ongoing desensitisation therapy, history of a scaly skin rash (Ex. psoriasis), pheochromocytoma, thyroid disorder, to receive general anaesthesia.
DORLAX 5MG TABLET is not recommended for use in pregnant and breast-feeding women unless considered clearly necessary. Consult your doctor before taking it. DORLAX 5MG TABLET is not recommended for use in children. Consult your doctor before taking it.
The most common side effects of taking DORLAX 5MG TABLET are tiredness, feeling weak, dizziness, headache, feeling of coldness or numbness in hands or feet, low blood pressure, nausea, vomiting, diarrhoea or constipation. Ask for your doctor?s advice if any of these worsen or doesn?t improve.
USES OF DORLAX 5MG TABLET
Treats:
High blood pressure (Hypertension)

Angina pectoris (Chest pain)

Stable heart failure (in combination with other medicines)

HOW DORLAX 5MG TABLET WORKS
DORLAX 5MG TABLET works by blocking certain receptors (beta-1 receptors) present mainly in the heart and prevents the binding of nerve chemicals such as epinephrine. Therefore, leading to decrease in heart rate, blood pressure and makes the heart more efficient at pumping blood around the body and it also reduces the amount of blood required by the heart, reducing oxygen demand. DORLAX 5MG TABLET also decrease the release of a substance called renin in the kidneys (which normally increases blood pressure), decreasing blood pressure and heart rate.
DIRECTIONS FOR USE
Take DORLAX 5MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your body weight, age?and severity of disease condition.
SIDE EFFECTS OF DORLAX 5MG TABLET

COMMON

Tiredness, feeling weak

Dizziness

Headache

Low pulse rate or slow heartbeat

Worsening of the pre-existing heart-failure

Coldness, numbness in your hands or feet

Low blood pressure

Gastrointestinal symptoms (nausea, vomiting, diarrhoea or constipation)

UNCOMMON

Sleep disturbances

Depression

Feeling weak

Dizziness when standing up

Breathing problems in asthma or chronic lung disease patients

Muscle weakness, muscle cramps

Exacerbation of existing heart rhythm disorders such as AV-block

RARE

Hearing problems

Blocked or runny nose

Reduced tear flow (dry eyes)

Inflammation of the liver (hepatitis), causing abdominal pain, loss of appetite and jaundice (yellowing of the whites of the eyes and skin and dark urine)

Increased levels of blood triglycerides and liver enzymes

Allergic reactions such as itching, flush, rash and severe allergic reactions, which may involve face, neck, tongue, mouth or throat swelling?or difficulty breathing

Impaired erection

Nightmares, hallucinations

Fainting
Stop taking DORLAX 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:
Slowing of heart rate

Worsening of heart failure (increased breathlessness and swelling of legs)

Slow or irregular heartbeat

Worsening of symptoms of blockage of the main blood vessel to the legs

Dizziness or weakness or have breathing difficulty

HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea:
Take this medicine with or after meals. Stick to simple meals while taking this medicine. Avoid eating rich or spicy food. Do not take any medication on your own. Ask for your doctor?s advice if nausea doesn?t improve.
Vomiting:
Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, oily?or sweet foods. Avoid carbonated drinks. Ask for your doctor?s advice if vomiting doesn?t improve.
Runny nose or sneezing:
Take rest and have plenty of fluids to stay hydrates. Blow your nose using a soft tissue. Take steam. You can have warm fluids such as tea. If the symptom doesn?t improve, ask for your doctor?s advice.
Muscle pain:
Give your body a rest. Do not overexert or over stretch yourself. Do stress relieving activities such as yoga or meditation. If the symptom doesn?t improve, ask for your doctor?s advice.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhea. Contact your doctor if the symptom did not improve.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables?and cereals and drink plenty of water. Exercise more regularly.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
WARNING & PRECAUTIONS

PREGNANCY
DORLAX 5MG TABLET is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking DORLAX 5MG TABLET.
BREASTFEEDING
DORLAX 5MG TABLET is not recommended for use in breastfeeding women as it is not known if this medicine passes into breast milk. Consult your doctor before taking DORLAX 5MG TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines until you know the effect of DORLAX 5MG TABLET on your ability to drive.
KIDNEY
DORLAX 5MG TABLET should be taken with caution in patients with severely impaired kidney diseases. Consult your doctor before taking DORLAX 5MG TABLET.
LIVER
?
DORLAX 5MG TABLET should be used with caution in patients with severely impaired liver function. Consult your doctor before taking DORLAX 5MG TABLET.
ALLERGY
?
Do not take DORLAX 5MG TABLET if you are allergic to Bisoprolol or any of the other ingredients of this medicine.
LUNGS
DORLAX 5MG TABLET is not recommended for use in patients with breathing problems such as Asthma and COPD. Consult your doctor before taking DORLAX 5MG TABLET.
HEART DISEASE
DORLAX 5MG TABLET is not recommended for use in patients with heart diseases such as acute heart failure, heart conduction disorders such as 2 or 3rd degree AV-block, sick sinus syndrome, sinoatrial block, slow heart rate (bradycardia), low blood pressure (hypotension)?and cardiogenic shock. DORLAX 5MG TABLET should be used with caution in patients having other heart diseases such as congenital heart disease, restrictive cardiomyopathy, hemodynamically significant organic valvular disease, myocardial infarction (withing 3 months), 1st degree AV block?or Prinzmetal?s angina. Consult your doctor before taking DORLAX 5MG TABLET.
OTHERS
DORLAX 5MG TABLET is not recommended for use if you have:
Raynaud?s syndrome (severe blood circulation problem in the limbs)

Untreated pheochromocytoma

Metabolic acidosis

Low blood pressure

Peripheral arterial occlusive disease (late-stage vascular condition causing impaired perfusion of the arms and legs)
Before taking DORLAX 5MG TABLET, inform your doctor if you have:
Diabetes type 1

Strict fasting

Ongoing desensitisation therapy

Less severe blood circulation problem in the limbs

History of a scaly skin rash (Ex. psoriasis)

Thyroid disorder

To undergo general anaesthesia
Use in paediatrics:
DORLAX 5MG TABLET is generally not recommended for use in children. Consult with your child?s doctor before giving DORLAX 5MG TABLET to your child.
Use in geriatrics:
DORLAX 5MG TABLET can be used elderly patients without dose adjustment. Your doctor might suggest the lowest dose to you. Consult your doctor before taking DORLAX 5MG TABLET.
INTERACTIONS
A) Drug ? Drug interactions:
Before taking DORLAX 5MG TABLET, inform your doctor if you are taking any of the?following medicine:
Medicines used to treat heart diseases such as irregular or abnormal heartbeat, high blood pressure?or angina pectoris (Ex. quinidine, lidocaine, flecainide, disopyramide, phenytoin, propafenone, verapamil, diltiazem, digoxin, isoprenaline, dobutamine, clonidine, methyldopa, adrenaline, nor-adrenaline, moxonodine, rilmenidine, amiodarone, felodipine and amlodipine)

Medicines used for glaucoma (Ex. timolol, pilocarpine)

Medicines used to treat diabetes (Ex.?insulin, metformin, tolbutamide)

Medicines used in anaesthesia (Ex. propofol, lidocaine)

Medicines used to treat pain or inflammation (Ex. Ibuprofen, diclofenac, acetyl salicylic acid)

Mefloquine (used for treatment, prevention of malaria)

Medicines used for depression (Ex. imipramine, isocarboxazid, amitriptyline, clomipramine, moclobemide)
B) Drug ? Food interaction:
NA
Overdosage:
If you or anyone else accidentally take too much of DORLAX 5MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are decreased heart rate, severe difficulty in breathing, feeling dizzy or trembling due to decreased blood sugar.
SYNOPSIS

Drug :?? Bisoprolol

Pharmacological Category :?? Beta-blockers

Therapeutic Indication :?? Hypertension, Angina, Stable heart failure

Dosage Forms :?? Tablet

MORE INFORMATION

Keep DORLAX 5MG TABLET out of the sight and reach of children

Store DORLAX 5MG TABLET below 30?C

FAQs ABOUT DORLAX 5MG TABLET
Does DORLAX 5MG TABLET lower blood pressure?
Yes. DORLAX 5MG TABLET causes low blood pressure. If you experience any unusual symptoms like dizziness, headache, sweating etc. Stop taking DORLAX 5MG TABLET and Contact your doctor.
Does DORLAX 5MG TABLET increase blood sugar levels?
Yes. DORLAX 5MG TABLET may increase blood sugar levels. Contact your doctor if you experience any symptoms like increased thirst and hunger or increased urination.
Can I drink coffee while being treated with DORLAX 5MG TABLET?
It is better to avoid tea or coffee while taking DORLAX 5MG TABLET. This is because, caffeine-containing food items and beverages along with beta blockers like DORLAX 5MG TABLET may decrease the effectiveness of the medicine.
Is DORLAX 5MG TABLET safe for use in pregnant?
DORLAX 5MG TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it.
Does DORLAX 5MG TABLET cause slow heartbeat?
Yes. DORLAX 5MG TABLET cause slow heartbeat. If you feel any unusual symptoms like pounding, fluttering or skipped heart beats. Immediately, contact your doctor.
Do I need to stop taking DORLAX 5MG TABLET before having a surgery that requires general anaesthesia?
Do not stop taking DORLAX 5MG TABLET on your own. Inform your anaesthetist if you are taking DORLAX 5MG TABLET. This is important to avoid any harmful interactions with other medications. If at all it is required for you to stop taking DORLAX 5MG TABLET, your doctor will guide you.
REFERENCES

Barbara G. wells, Terry L. schwinghammer, Joseph T. dipiro, Cecily V. dipiro. Heart failure. Pharmacotherapy handbook. Tenth edition. 2017. Page ? 120

Pascal de Groote, Pierre-Vladimir Ennezat, Fr?deric Mouquet. Bisoprolol in the treatment of chronic heart failure. NIH National Library ofmedicine National Centre for Biotechnology Information. Pubmed Central. August 2007. [Accessed on 3rd May 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291328/

Linda?Wagner,?Charlotte?Kenreigh. Bisoprolol. Science Direct. [Accessed on 3rd May 2022]?https://www.sciencedirect.com/topics/medicine-and-dentistry/bisoprolol

Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in June 2021]?[Accessed on 3rd May 2022]?https://www.medicines.org.uk/emc/files/pil.6126.pdf

McDermott Laboratories Ltd. Bisoprolol. [Revised in July 2022]?[Accessed on 3rd May 2022]?https://www.medicines.ie/medicines/bisoprolol-mylan-31447/spc#tabs

Papaloizou Ltd. Concor (Bisoprolol). [Revised in August 2022]?[Accessed on 3rd May 2022]?https://www.papaloizou.com/PublicDocsPDF/SPCs/Concor_SPC.pdf

Drug Bank. Bisoprolol. [Accessed on 3rd May 2022]?https://go.drugbank.com/drugs/DB00612

USEFUL DIAGNOSTIC TESTS

ECG (Echocardiograph)

Echocardiogram

Kidney function test

Liver Function Test

PRODUCT DETAILS

Country Of Origin

India

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