Nicoduce OD 10mg Tablet 10?S Allschoolabs -

Specification

INTRODUCTION
NICODUCE OD contains Nicorandil which belongs to theroup of medicines called Potassium channel activators. It is used in adults to prevent and reduce painful signs of angina pectoris who cannot take heart medicines called beta-blockers or calcium antagonists. ???
Angina pectoris is a type of temporary chest pain or discomfort which occurs as a result of decreased blood flow to the heart muscle which is usually not a heart attack but a sign of increased risk for heart attack that isenerally characterized by symptoms such as squeezing pressure, heaviness, tightness or pain in the chest that can occur sudden or recur over time. ???
Avoid consumption of alcohol during treatment with NICODUCE OD as it may reduce your blood pressure even more. ??????
NICODUCE OD is not recommended for use in patients with severe low blood pressure, low blood volume, heart problems (such as cardiogenic shock, left ventricular failure with low filling pressure or cardiac decompensation). ??????
Before taking NICODUCE OD, inform your doctor if you have lung problems such as pulmonary oedema (condition marked by fluid build-up in lungs), hepatic impairment or kidney problems. ??????
NICODUCE OD is not recommended for use in pregnant and breastfeeding women. It is also not recommended for use in children and adolescents (below 18 years of age). Consult your doctor before taking it. ????
The most common side effects of taking NICODUCE OD are headache, dizziness, skin flushing, nausea, vomiting, weakness and rapid or forceful heartbeat. Consult your doctor if any of the symptoms worsen.
USES OF NICODUCE OD

To prevent and reduce painful signs of angina pectoris in adults

HOW NICODUCE OD WORKS
NICODUCE OD works by increasing blood flow through the heart vessels, leading to improved blood and oxygen supply to the heart muscle thus reducing the workload of the heart which results in reducing the frequency and severity of angina attacks.
DIRECTIONS FOR USE
Take NICODUCE OD as advised by your physician. Swallow the medicine with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF NICODUCE OD

COMMON

Headache

Dizziness

Flushed skin

Nausea

Vomiting

Weakness

Rapid, uneven or forceful heartbeat

Skin abscess (swollen, pus-filled lump within or below the skin surface)

Ulcers in mouth, small and large intestines or anal

UNCOMMON

Low blood pressure

Pus collection inenital, anal or other areas of digestive tract

Corneal ulcer (open sore in the corneal part of eye)

Conjunctival ulcer (type of inflammatory reaction of eye)

Conjunctivitis (pink eye)

RARE

Rash

Itching

Muscle pain not caused by exercise
Stop taking NICODUCE OD and contact your doctor immediately if you experience any of the following side effects:
Red, itchy, swollen or watery eyes including inflammation or ulcer in cornea or conjunctiva (parts of eye)

Signs of ulcers in mouth, stomach, large and small intestine or anus such as blood in stools, vomit, fistula (abnormal opening between organs), abscess (pus collection at infected site) and weight loss

Signs of diverticular disease (infected colon) such as ulcers in the skin,enital tract and nasal passages or around a stoma (artificial opening for waste removal)?

HOW TO MANAGE SIDE EFFECTS
Nausea:
Take NICODUCE OD with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if the symptom does not improve.
Vomiting:
Get adequate rest. Drink sufficient amount of fluids, especially water. Have small sips if you feel sick. Eat when you feel hungry. Do not take any medicine for vomiting without asking your doctor. Consult your doctor if the symptomets worse.
Headache:
Drink ample amount of water.et adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Dizziness:
Lie down until dizziness isone, thenet up slowly. Move slowly and carefully, do not hurry.et adequate rest. Drink plenty of water and other fluids. Avoid smoking cigarettes and drinking alcohol. Consult your doctor if the symptom does not improve.
WARNING & PRECAUTIONS

PREGNANCY
NICODUCE OD is not recommended for use in pregnant women. Consult your doctor before taking NICODUCE OD.
BREASTFEEDING
NICODUCE OD is not recommended for use in breastfeeding women. Consult your doctor before taking NICODUCE OD.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizzy or weak after taking NICODUCE OD.
ALCOHOL
Avoid consumption of alcohol while taking NICODUCE OD because it might further lower your blood pressure.
KIDNEY
NICODUCE OD should be taken with caution in patients with kidney problems. Consult your doctor before taking NICODUCE OD.
LIVER
NICODUCE OD should be taken with caution in patients with liver disease such as fibrosis of liver and chronic liver disease. Consult your doctor before taking NICODUCE OD.
ALLERGY
Do not take NICODUCE OD if you are allergic to Nicorandil or any other ingredients of this medicine.
LUNGS
NICODUCE OD is not recommended for use in patients having lung disease such as pulmonary oedema (fluid build-up in lungs). Consult your doctor before taking NICODUCE OD.
HEART DISEASE
NICODUCE OD is not recommended for use in patients with heart problems such as cardiogenic shock, left ventricular failure with low filling pressure and cardiac decompensation. It is used with caution in patients with heart failure. Consult your doctor before taking NICODUCE OD.
OTHERS
NICODUCE OD is not recommended for use if you have:
Signs of severe low blood pressure such as dizziness, light-headedness or feeling faint

Signs of low blood volume such as confusion, difficulty breathing or fast breathing, excessive sweating and loss of consciousness
Before taking NICODUCE OD, inform your doctor if you have:
Low blood pressure

Signs of low blood potassium levels such as constipation, weakness, muscle damage

Havelucose-6 phosphate dehydrogenase deficiency (aenetic condition)
Use in pediatrics:
NICODUCE OD is not recommended for use in children and adolescents (below 18 years of age). Consult your child?s doctor for advice.
Use ineriatrics:
NICODUCE OD should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking NICODUCE OD.
INTERACTIONS
A. Drug ? Drug interactions:
Before taking NICODUCE OD, inform your doctor if you are taking any of the following medicines:
Medicines used to treat erectile dysfunction (Ex. sildenafil, tadalafil, vardenafil)

Riociguat (used to treat high blood pressure in lung arteries)

Medicines used to treat inflammatory conditions such as corticosteroids (Ex. hydrocortisone, prednisolone)

Medicines used to relieve pain and inflammation (Ex. aspirin, ibuprofen)

Medicines used to treat heart conditions like high blood pressure, angina (Ex. enalapril, propranolol, valsartan and nitroglycerin)

Medicines that increase blood potassium levels (Ex. spironolactone)

Cyclosporin (used to prevent organ rejection after transplant)

Dapoxetine (used to treat premature ejaculation)

Medicines used to treat depression (Ex. nortriptyline, duloxetine)
Overdosage:
If you or anyone else accidentally take too much of NICODUCE OD, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are weakness, dizziness, fast or uneven heartbeat.
SYNOPSIS

Drug :?? Nicorandil

Pharmacological Category :?? Potassium channel activators

Therapeutic Indication :?? Angina pectoris

Dosage Forms :?? Tablet, Injection

MORE INFORMATION

Keep NICODUCE OD out of reach of children

Store at (2 ? 8?C) in the refrigerator. Do not freeze

FAQs ABOUT NICODUCE OD
Is it safe to use NICODUCE OD in pregnant and breastfeeding women?
No, NICODUCE OD is not recommended for use during pregnancy and in women with childbearing potential. It is also not recommended for use in breastfeeding women as it is not known whether it may pass in the breast milk. Consult your doctor for advice if you are planning toet pregnant. ?
Is NICODUCE OD safe to use in children?
No, NICODUCE OD is used for adults and not recommended for use in children and adolescents below 18 years of age. Child?s doctor will select a suitable alternative therapy for your child depending upon the condition. ??
What if I forget to take a dose of NICODUCE OD?
If you miss or forget to take a dose of NICODUCE OD, take it as soon as you remember. However, omit the missed dose if it is almost time for your next dose. Do not take the medicine twice to make up for a forgotten dose. ???????
Can NICODUCE OD be used in patients with liver problems?
NICODUCE OD should be taken with caution in patients with liver problems such as fibrosis of liver and chronic liver disease. Your doctor may regularly monitor your liver function during treatment with NICODUCE OD. Consult your doctor for advice before taking this medicine.
Is [GBNKEYWORD] safe to use in patients with heart problems?
NICODUCE OD is not recommended for use in patients with heart problems such as cardiogenic shock, left ventricular failure with low filling pressure and cardiac decompensation. It is used with caution in patients with heart failure. Consult your doctor before taking NICODUCE OD.
REFERENCES
1. KD. Tripathi. Antianginal and other Anti-ischemic Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page ? 552.
2. Kevin Cheng, Khaldoon Alhumood, Fayez El Shaer, and Ranil De Silva. The Role of Nicorandil in the Management of Chronic Coronary Syndromes in theulf Region. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. December 2020. [Accessed on 6th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889547/
3. Jason M. Tarkin and Juan Carlos Kaski. Vasodilator Therapy: Nitrates and Nicorandil. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. June 2016. [Accessed on 6th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658472/
4. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 6th June 2022] https://www.medicines.org.uk/emc/files/pil.652.pdf
5. West-Coast Pharmaceutical Works Ltd. Nicovex-5 (Nicorandil Tablets BP 5 mg). [Accessed on 6th June 2022] https://westcoastin.com/product/nicorandil-tablets-5mg/
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