PROTOXIL 500mg|100ml Infusion 100mlx10s works by inhibiting the growth of bacteria and protozoa by interfering with the DNA synthesis.
Side effects
Major & minor side effects for PROTOXIL 500mg|100ml Infusion 100mlx10s

Agitation severe

Blurred vision severe

Burning or tingling sensation of hands and feet severe

Convulsions severe

Fever and chills severe

Skin rash severe

Vaginal irritation severe

Loss of appetite severe

Constipation severe

Yellow colored eyes or skin severe

Abdominal pain

Dizziness

Change in taste/ Metallic taste

Dry mouth

Uses of PROTOXIL 500mg|100ml Infusion 100mlx10s
What is it prescribed for?

Amebiasis
PROTOXIL 500mg|100ml Infusion 100mlx10s is used in the amebiasis which is a parasitic infection that affects the intestine and amebic liver abscess caused by Entamoeba histolytica.

Trichomoniasis
PROTOXIL 500mg|100ml Infusion 100mlx10s is used in the treatment of trichomoniasis which is a sexually transmitted disease caused by Trichomonas vaginalis.

Bacterial Vaginosis
PROTOXIL 500mg|100ml Infusion 100mlx10s is used in the treatment of overgrowth of bacteria in the vagina caused by Lactobacillus species.

Bacterial infections
PROTOXIL 500mg|100ml Infusion 100mlx10s is used to treat the infectins caused by bacteria in blood, lungs, genital areas caused by Bacteroides fragilis and Clostridium species.

Surgical prophylaxis
PROTOXIL 500mg|100ml Infusion 100mlx10s is used to treat infections that may cause after surgery.

Concerns

Frequently asked questions

Onset of action
The peak effect of this medicine can be observed in 1 to 2 hours.

Duration of Effect
The effect of this medicine lasts for an average duration of 24 hours.

Safe with Alchohol?
Consumption of alcohol is not recommended in patients with PROTOXIL 500mg|100ml Infusion 100mlx10s . Any symptoms of the fast heartbeat, warmth, headache, and breathing difficulty should be reported to the doctor.

Is it habit forming?
No habit forming tendencies were reported.

Usage in pregnancy?
This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed.

Usage while breast-feeding?
This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed.

When not to use?

Allergy
Not recommended in patients with known allergy to PROTOXIL 500mg|100ml Infusion 100mlx10s or other nitroimidazoles.

Warnings

Warnings for special population

Pregnancy
This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed.

Breast-feeding
This medicine is known to excreted through the breastmilk. It is used in breastfeeding women only if clearly needed. Breastfeeding should be avoided for 24 hours after single-dose maternal treatment. Monitoring of candidal infections and diarrhea is necessary.

General Warnings

Blood cell count
This medicine may lower the blood cell count and may lead to leukopenia, thrombocytopenia, and bone marrow aplasia. Close monitoring of WBC count, platelets is necessary. Discontinue the treatment if any signs of low blood cell count appear.

Neurologic Toxicity
This medicine may cause neurological effects like convulsions and peripheral neuropathy. Inform the doctor if you have any neurological problems. Any symptoms of convulsions, tingling or burning sensation of hands and feet should be reported to the doctor.

Impaired liver function
This medicine may cause liver injury. The baseline of liver enzymes should be obtained before initiating the therapy. Any signs of elevation in the liver enzymes should be informed to the doctor. Discontinue the treatment until the levels reach to normal.

Dosage

Missed Dose
If you miss a dose of PROTOXIL 500mg|100ml Infusion 100mlx10s , take the missed dose as soon as you remember. If it?s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions
Interaction with Medicines

Warfarin severe

Ethinyl Estradiol moderate

Atorvastatin moderate

Disulfiram moderate

General Instructions

Take PROTOXIL 500mg|100ml Infusion 100mlx10s as advised by your doctor. Do not take in larger amounts than advised. It is advised to take this medicine at the same time every day. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.

Other details

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

References

practo.com –
Metronidazole [Internet].
Available from: https://www.practo.com/medicine-info/metronidazole-182-api
[cited 2 october 2019].
16 Nov 2017

medlineplus.gov –
Metronidazole [Internet].
Available from: https://medlineplus.gov/druginfo/meds/a601159.html
[cited 2 october 2019].
11 September 2019

dailymed.nlm.nih.gov –
Metronidazole [Internet].
Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a66abf44-9ae9-4342-b69a-ebaa1f9b7d78
[cited 2 october 2019].
November 27, 2006