WOMEGEN 1.25mg Tablet 2x10s binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription.
Side effects
Major & minor side effects for WOMEGEN 1.25mg Tablet 2x10s

Body aches or Pain

Cough

Difficulty in breathing

Headache

Unusual tiredness or weakness

Dark urine rare

Vaginal discharge rare

Dizziness rare

Uses of WOMEGEN 1.25mg Tablet 2x10s
What is it prescribed for?

Post menopausal symptoms
This medicine is used to relieve and treat the symptoms experienced after menopause. Most common symptoms include hot flashes and vaginal dryness.

Female hypogonadism
This medicine is used to treat the deficiency of sex hormone due to delayed development of certain glands in females.

Pillative treatment of Breast cancer
This medicine is used to treat certain symptoms in a patient suffering from end-stage cancer of the breast or prostate.

Abnormal uterine bleeding
This medicine is used to treat vaginal bleeding which occurs beyond/irregular menstrual cycles.

Primary ovarian failure
This medicine is used to treat the symptoms of primary ovarian failure which results in low estrogen level in the body and infertility.

Vaginal atrophy
This medicine is used in the treatment of atrophic vaginitis, or vaginal atrophy, which is the thinning of the walls of the vagina caused by decreased estrogen levels.

Postmenopausal osteoporosis
This medicine is also used to prevent and treat the symptoms of osteoporosis in women who have reached menopause.

Pillative treatmant of Prostate Cancer
This medicine is also used for the management of symptoms of prostate cancer.

Concerns

Frequently asked questions

Onset of action
The amount of time required for this medicine to show its action is not clinically established.

Duration of Effect
The amount of time for which this medicine remains active in the body is not clinically established.

Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?
No habit-forming tendencies were reported.

Usage in pregnancy?
Use of this medicine is not recommended if you are pregnant or planning a pregnancy in immediate future. Contact your doctor if you suspect a pregnancy while being treated with this medicine.

Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

When not to use?

Allergy
This medicine is not recommended for use in patients who have a known allergy to estrogen products or any other inactive ingredients present in the formulation.

Undiagnosed vaginal bleeding
This medicine is not recommended for use if you have an abnormal episode of vaginal bleeding which was not diagnosed.

Heart and blood vessel disorder
This medicine is not recommended for use in patients having a disease of the heart or blood vessels viz. deep vein thrombosis, recent heart attack, other blood clotting disorders, etc.

Breast cancer
This medicine is not recommended for use in patients having breast cancer. It should also not be used if a patient has had breast cancer before or is suspected of having it. Patients having end-stage breast cancer and on palliative care are an exception here.

Liver Disease
This medicine is not recommended for use in patients having an impairment of liver function owing to a disease or other contributing factors.

Estrogen-dependent tumor
This medicine is not recommended for use in patients having cancer which is attributed to abnormal levels of the hormone estrogen in the body for a prolonged duration.

Warnings

Warnings for special population

Pregnancy
Use of this medicine is not recommended if you are pregnant or planning a pregnancy in immediate future. Contact your doctor if you suspect a pregnancy while being treated with this medicine.

Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

General Warnings

Abnormal vaginal bleeding
This medicine should not be given to women having undiagnosed abnormal vaginal bleeding. Appropriate tests should be performed to rule out cancer in all cases of abnormal and persistent bleeding before treatment is initiated.

Breast cancer
Use of this medicine increases the risks of breast cancer and hence should be used at the lowest doses and the duration of treatment should be kept as low as possible.

Kidney Disease
Use of this medicine has been associated with the formation of blood clots especially in the elderly and people with a habit of smoking.

Use in Children
This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Jaundice like symptoms
Use of this medicine can cause yellowing of the eyes and skin due to its effect on the liver and the gall bladder. Report the presence of any symptom indicative of jaundice to the doctor on priority. Use of this medicine should be stopped in such cases.

Driving or Operating machinery
Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Dosage

Missed Dose
Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions
Interaction with Medicines

Thalidomide severe

Efavirenz moderate

Acarbose moderate

Lenalidomide severe

Carfilzomib severe

Disease interactions

severe
This medicine is not recommended for use in patients having a tumor caused due to abnormal levels of estrogen in the body. The tumor may be of the endometrium or the breasts. Suitable diagnostic tests should be performed before starting treatment with estradiol.

severe
This medicine should be used with extreme caution in patients having high blood pressure. The risk of adverse effects on the heart and blood vessels are extremely high in such cases. Suitable dose adjustment and safety monitoring is a must in such cases.

severe
Use of this medicine is not recommended if the patient has cancer of the liver is suspected of having it. Your doctor may decide the best course of treatment after assessing the condition.

General Instructions

Take this medicine as instructed by the doctor. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. It is advised to do regular follow-ups with the doctor while taking this medicine.

Other details

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

References

webmd.com –
Estrogens Conjugated [Internet].
Available from: https://www.webmd.com/drugs/2/drug-2378/conjugated-estrogens-oral/details
[cited 29/7/2020].

cancer.gov –
Estrogens Conjugated [Internet].
Available from: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/conjugated-estrogens
[cited 29/7/2020].