Uses & Effectiveness Overview Avocado soy unsaponifiables are certain chemicals that come from mixing one third avocado oil with two thirds soybean oil. Avocado soy unsaponifiables include chemicals like vitamin E, plant fats, and others. The mixture of these chemicals seems to reduce swelling in the joints and other places in the body. People use avocado soy unsaponifiables for osteoarthritis. They are also used for back pain, hot flashes, obesity, and other conditions, but there is no good scientific evidence to support these uses. Don?t confuse avocado soy unsaponifiables with compounds made only from avocado, avocado sugar, soybean, or soybean oil. These are not the same. A fascinating fact about Avocado Soy Unsaponifiables (ASU) is that they are natural extracts derived from avocados and soybeans, and they have shown promising results in reducing pain and inflammation associated with osteoarthritis, making them a popular supplement for joint health. Side Effects When taken by mouth: Avocado soy unsaponifiables are possibly safe. Specific products (Piascledine 300 or Flexi-Smart) have been used safely for up to 3 years. It?s usually well-tolerated. Interactions We currently have no information for AVOCADO SOY UNSAPONIFIABLES (ASU) overview. Special Precautionsand Warnings When taken by mouth: Avocado soy unsaponifiables are possibly safe. Specific products (Piascledine 300 or Flexi-Smart) have been used safely for up to 3 years. It?s usually well-tolerated. Pregnancy and breast-feeding: There isn?t enough reliable information to know if avocado soy unsaponifiables are safe to use when pregnant or breast feeding. Stay on the safe side and avoid use. Dosing Avocado soy unsaponifiables have most often been used by adults in doses of 300 mg by mouth daily for up to 3 years. Speak with a healthcare provider to find out what dose might be best for a specific condition.